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Clinical Nutrition: 益生菌对超重和肥胖个体心血管风险具有有益影响

2021-07-03 MedSci原创 MedSci原创

大家都知道,基因能决定我们长成什么样,基因同样也能决定哪些微生物能和我们共生,帮助我们调节免疫系统。这些微生物一般都从我们一出生就定植在黏膜组织上,比如口腔、

      大家都知道,基因能决定我们长成什么样,基因同样也能决定哪些微生物能和我们共生,帮助我们调节免疫系统。这些微生物一般都从我们一出生就定植在黏膜组织上,比如口腔、胃肠道、生殖道内壁等等,这些通道都是与外界相连的,微生物就会作为免疫系统的一部分,保护我们不会病从“口”入。另外,早期定植的微生物菌群可能会影响我们一生的炎症反应,有证据表明,肠道微生物群是肥胖和相关代谢紊乱病理生理学的潜在因素。

 

      虽然个别随机对照试验 (RCT) 已经评估了益生菌对超重和肥胖受试者肥胖和血管疾病 (CVD) 危险因素的影响,但结果并不一致。因此,本系统评价和荟萃分析旨在评估益生菌补充剂对超重和肥胖受试者的体重、身体肥胖和 CVD 风险标志物的影响。

 

 

      研究人员在各个数据库中对截至 2020 年 12 月发表的 随机对照实验(RCT) 进行了系统搜索。选择使用随机效应模型的荟萃分析来分析联合试验的影响。最后包括了 26 个 RCT研究(n=1720)。数据汇总显示益生菌对体重(MD:-0.70kg;95%CI:-1.04,-0.35kg;P <0.0001)、体重指数(BMI)(MD:-0.24kg/m2 ; 95%CI:-0.35,-0.12kg/m2 ; P =0.0001), 腰围 (WC) (MD:-1.13cm; 95%CI:-1.54,-0.73cm; P <0.0001), 脂肪量(MD:-0.71kg; 95%CI:-1.10,-0.32kg; P =0.0004), 肿瘤坏死因子-α (MD:-0.16pg/ml; 95%CI:-0.24,-0.08pg/ml; P =0.0001)、胰岛素(MD:-0.85mcU/ml;95%CI:-1.50、-0.21mcU/ml;P =0.010)、总胆固醇(MD:-0.16mmol/l;95%CI:-0.26 ,-0.05mmol/l; P=0.003) 和 低密度脂蛋白(LDL) (MD:-0.09mmol/l; 95%CI:-0.16,-0.03mmol/l; P =0.006) 的改善都有很大的作用。在使用单一和多种细菌物种的研究中,体重、BMI 和 WC也可以观察到显着降低。但是所有的变化都要在益生菌剂量≥ 1010 CFU 且持续时间≥ 8 周的研究中才能起到效果。

 

 

      本项研究证实摄入益生菌可能有助于改善超重和肥胖个体的体重、身体肥胖和一些 CVD 风险标志物。

 

 

原始出处:

Karine Scanci da Silva Pontes. Et al. Effects of probiotics on body adiposity and cardiovascular risk markers in individuals with overweight and obesity: a systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition.2021.

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    2021-07-05 zll0628
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    2021-07-04 ms2000001361349190

    益生菌

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