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Transpl Infect Dis:同种异体SCT后抗真菌预防,氟康唑的理想剂量 你造吗?

2018-09-05 王淳 环球医学

侵袭性真菌感染(IFI)是同种异体干细胞移植(同种异体SCT)一种常见的副作用,会增加非复发性死亡率(NRM)并降低总存活(OS)率。75日氟康唑400 mg/d是同种异体SCT后的标准初级抗真菌预防(PAP)方案,尤其是低风险移植。但是,氟康唑的理想剂量还未被考察。2018年8月,发表在《Transpl Infect Dis》的一项研究对此进行分析。

侵袭性真菌感染(IFI)是同种异体干细胞移植(同种异体SCT)一种常见的副作用,会增加非复发性死亡率(NRM)并降低总存活(OS)率。75日氟康唑400 mg/d是同种异体SCT后的标准初级抗真菌预防(PAP)方案,尤其是低风险移植。但是,氟康唑的理想剂量还未被考察。2018年8月,发表在《Transpl Infect Dis》的一项研究对此进行分析。

本文中,研究人员报道了所在机构在1999至2015年间,连续的113名接受HLA相同同胞的同种异体干细胞移植的患者,PAP包括仅移植前的氟康唑100 mg/d。移植时,根据ECIL-5指南,所有患者被评为低风险的霉菌感染

结果显示,移植后100日,可能-很可能-证实的IFI累积发生率是11.7%,而5.5%患者出现证实-很可能的IFI(PP-IFI)。值得注意的,仅1名患者出现非白色菌珠导致的侵袭性念珠菌病,并且粪便检测显示白色念珠菌定植阴性。1年急性和2年慢性移植物抗宿主病(GVHD)的发病率分别是30%和45%。3年OS和1年NRM分别是53%和11.3%。

总体上,氟康唑100 mg/d的真菌预防能降低低风险同种异体SCT的PP-IFI、GVHD和NRM的发生率。

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    2019-07-13 amy0563
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    2018-09-27 bsmagic9140
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    2018-09-07 zhaojie88
  6. [GetPortalCommentsPageByObjectIdResponse(id=2012789, encodeId=925e2012e89da, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sat Dec 22 15:18:00 CST 2018, time=2018-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687976, encodeId=900e168e976b8, content=<a href='/topic/show?id=b3e73898423' target=_blank style='color:#2F92EE;'>#同种异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38984, encryptionId=b3e73898423, topicName=同种异体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23b928427427, createdName=12498768m22(暂无昵称), createdTime=Wed Feb 13 18:18:00 CST 2019, time=2019-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1775748, encodeId=c12c1e7574823, content=<a href='/topic/show?id=19e45556efa' target=_blank style='color:#2F92EE;'>#抗真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55567, encryptionId=19e45556efa, topicName=抗真菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=596c38798743, createdName=amy0563, createdTime=Sat Jul 13 02:18:00 CST 2019, time=2019-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657065, encodeId=a436165e0656f, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Thu Sep 27 09:18:00 CST 2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353750, encodeId=f0f51353e5017, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Sep 07 03:18:00 CST 2018, time=2018-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603299, encodeId=08b5160329939, content=<a href='/topic/show?id=ba9a6392545' target=_blank style='color:#2F92EE;'>#氟康唑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63925, encryptionId=ba9a6392545, topicName=氟康唑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d68c19021189, createdName=yhj-time, createdTime=Fri Sep 07 03:18:00 CST 2018, time=2018-09-07, status=1, ipAttribution=)]

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