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Sci Rep:与腹膜后根治性肾输尿管切除术相比,经腹膜根治性肾输尿管切除术与更严重的疾病恶化相关

2019-05-03 AlexYang MedSci原创

最近,有研究人员比较了腹膜后根治性肾输尿管切除术(rRNU)和经腹膜根治性肾输尿管切除术(tRNU)在上尿路上皮癌(UTUC)患者的肿瘤治疗方面结果情况。研究人员对1995年到2015年经历rRNU或者tRNU的743名符合入选标准的患者的医疗记录进行了回顾性的分析。研究发现,分别有620名(83.4%)和123名(16.6%)患者进行了rRNU和tRNU治疗。5年的癌症特异性生存(CSS)和总生

最近,有研究人员比较了腹膜后根治性肾输尿管切除术(rRNU)和经腹膜根治性肾输尿管切除术(tRNU)在上尿路上皮癌(UTUC)患者的肿瘤治疗方面结果情况。

研究人员对1995年到2015年经历rRNU或者tRNU的743名符合入选标准的患者的医疗记录进行了回顾性的分析。研究发现,分别有620名(83.4%)和123名(16.6%)患者进行了rRNU和tRNU治疗。5年的癌症特异性生存(CSS)和总生存(OS)比例在rRNU和tRNU治疗组之间相当,但是5年无进展生存(POFS)在tRNU组中要比rRNU组更低(p=0.005)。当患者通过病理T阶段进行分层,研究人员发现PFS在2个小组中显著不同,且rRNU组在器官局限性疾病(pTis/pTa/pT1/T2) (P=0.022)和局部晚期疾病(pT3/pT4)(P=0.039)方面更有优势。然而,研究人员在器官局限性疾病(P=0.336和P=0.851)或者局部晚期疾病(P=0.499和P=0.278)患者中并没有观察到CSS或者OS的差异。另外,tRNU是PFS的一个显著的预测因子(HR=1.54;P=0.023),而非CSS或者OS。

最后,研究人员指出,他们的研究表明了在UTUC患者中,tRUN方法比rRNU方法能够产生更好的PFS。

原始出处:


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    2019-05-05 jeanqiuqiu
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    2019-05-05 xuyong530
  6. [GetPortalCommentsPageByObjectIdResponse(id=1931906, encodeId=268f193190696, content=<a href='/topic/show?id=6f9885648e1' target=_blank style='color:#2F92EE;'>#腹膜后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85648, encryptionId=6f9885648e1, topicName=腹膜后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Mon Jan 27 10:15:00 CST 2020, time=2020-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877145, encodeId=048518e71456b, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Fri Aug 30 08:15:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640844, encodeId=fc06164084489, content=<a href='/topic/show?id=6ead93e7366' target=_blank style='color:#2F92EE;'>#输尿管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93773, encryptionId=6ead93e7366, topicName=输尿管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9f722746129, createdName=12498bb3m97(暂无昵称), createdTime=Sat Jan 11 02:15:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586140, encodeId=971a1586140c8, content=<a href='/topic/show?id=38f8622191b' target=_blank style='color:#2F92EE;'>#根治#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62219, encryptionId=38f8622191b, topicName=根治)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26d917348678, createdName=jeanqiuqiu, createdTime=Sun May 05 03:15:00 CST 2019, time=2019-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623817, encodeId=6054162381e56, content=<a href='/topic/show?id=16ba8564526' target=_blank style='color:#2F92EE;'>#腹膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85645, encryptionId=16ba8564526, topicName=腹膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e220615097, createdName=xuyong530, createdTime=Sun May 05 03:15:00 CST 2019, time=2019-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365699, encodeId=31bc365699df, content=学习一下,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=19823099910, createdName=morphinane, createdTime=Sat May 04 08:17:33 CST 2019, time=2019-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365675, encodeId=037c3656e57d, content=学习了谢谢分, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri May 03 21:21:12 CST 2019, time=2019-05-03, status=1, ipAttribution=)]
    2019-05-04 morphinane

    学习一下,谢谢

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1931906, encodeId=268f193190696, content=<a href='/topic/show?id=6f9885648e1' target=_blank style='color:#2F92EE;'>#腹膜后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85648, encryptionId=6f9885648e1, topicName=腹膜后)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Mon Jan 27 10:15:00 CST 2020, time=2020-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877145, encodeId=048518e71456b, content=<a href='/topic/show?id=67c5319121e' target=_blank style='color:#2F92EE;'>#切除术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31912, encryptionId=67c5319121e, topicName=切除术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9d8a96, createdName=doctorzheng, createdTime=Fri Aug 30 08:15:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640844, encodeId=fc06164084489, content=<a href='/topic/show?id=6ead93e7366' target=_blank style='color:#2F92EE;'>#输尿管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93773, encryptionId=6ead93e7366, topicName=输尿管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9f722746129, createdName=12498bb3m97(暂无昵称), createdTime=Sat Jan 11 02:15:00 CST 2020, time=2020-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1586140, encodeId=971a1586140c8, content=<a href='/topic/show?id=38f8622191b' target=_blank style='color:#2F92EE;'>#根治#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62219, encryptionId=38f8622191b, topicName=根治)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26d917348678, createdName=jeanqiuqiu, createdTime=Sun May 05 03:15:00 CST 2019, time=2019-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623817, encodeId=6054162381e56, content=<a href='/topic/show?id=16ba8564526' target=_blank style='color:#2F92EE;'>#腹膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85645, encryptionId=16ba8564526, topicName=腹膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=93e220615097, createdName=xuyong530, createdTime=Sun May 05 03:15:00 CST 2019, time=2019-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365699, encodeId=31bc365699df, content=学习一下,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=19823099910, createdName=morphinane, createdTime=Sat May 04 08:17:33 CST 2019, time=2019-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365675, encodeId=037c3656e57d, content=学习了谢谢分, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Fri May 03 21:21:12 CST 2019, time=2019-05-03, status=1, ipAttribution=)]
    2019-05-03 一个字-牛

    学习了谢谢分

    0

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