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PLoS One:华人学者发现骨移植手术可选用自身细胞

2014-04-17 佚名 生物探索

骨移植手术的骨材料可来自自身的干细胞,而不需要通过外界移植来的骨材料。目前,这一实验在应用于小鼠身上获得成功,应用于人类临床试验,估计还需等待时日。 研究由华人学者、来自得克萨斯大学Arlington生物工程中心主任(University of Texas at Arlington bioengineering)Liping Tang完成。发表在PLoS ONE杂志上。

骨移植手术的骨材料可来自自身的干细胞,而不需要通过外界移植来的骨材料。目前,这一实验在应用于小鼠身上获得成功,应用于人类临床试验,估计还需等待时日。




研究由华人学者、来自得克萨斯大学Arlington生物工程中心主任(University of Texas at Arlington bioengineering)Liping Tang完成。发表在PLoS ONE杂志上。

Tang通过将可分解的生物聚合物以及骨形态发生蛋白(Bone Morphogenetic Protein,BMP)植入到小鼠腹内,从而吸引小鼠干细胞来产生骨组织。通常骨形态发生蛋白是骨组织发育的重要组成材料。Tang说,这种方式形成骨组织往往只需要数天时间。

通常,在骨移植手术中,大约有25%的并发症出现,但是通过自身的干细胞来合成的骨组织,能够减少这方面的并发症发生,病人在手术移植时,也有更好的舒适度。

同时,这项研究还可实现个性化骨组织的定制需求,在成本上也大为减少,为病人省去普通骨移植时昂贵的费用。

原始出处:

Shen J1, Nair A1, Saxena R2, Zhang CC3, Borrelli J Jr4, Tang L5.Tissue engineering bone using autologous progenitor cells in the peritoneum.PLoS One. 2014 Mar 28;9(3):e93514. doi: 10.1371/journal.pone.0093514. eCollection 2014.

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