Cancer：常用止痛药有预防皮肤癌功效

一项新的研究表明阿司匹林和其他类似的止痛药可能有助于防止皮肤癌。相关研究论文发表在Cancer杂志上。

以往研究表明服用非类固醇消炎药物或NSAIDs，其中包括阿司匹林、布洛芬、萘普生以及各种其他的非处方药和处方药，可以减少患某些类型癌症的风险。丹麦奥胡斯大学医院的研究证实这些药物可能会降低三个主要类型的皮肤癌的风险：基底细胞癌、鳞状细胞癌以及恶性黑色素瘤。

研究人员分析了从1991年到2009年间，丹麦北部地区就诊患者，有1974例鳞状细胞癌，13316例基底细胞癌和3242例恶性黑色素瘤被诊断。他们比较了皮肤癌患者与178655名未患皮肤癌患者的信息包括处方数据。
 
那些服用两种以上非甾体抗炎药的人患鳞状细胞癌的风险下降15％，患恶性黑色素瘤的风险下降13％，相比于使用两种或更少的处方药物的患者。尤其是当服用非甾体抗炎药时间超过7年或是服用频率较高的人患皮肤癌的风险下降越明显。

我们希望非甾体抗炎药预防癌症的效果会引发更多有关预防皮肤癌的研究。此外，这种潜在的预防癌症的效果应当权衡NSAID的好处和危害。

doi:10.1002/cncr.27406
PMC:
PMID:

Nonsteroidal anti-inflammatory drugs and the risk of skin cancer: A population-based case-control study

Sigrún Alba Jóhannesdóttir, Ellen T. Chang, Frank Mehnert, Morten Schmidt, Anne Braae Olesen, Henrik Toft Sørensen.

Previous studies suggest that taking nonsteroidal anti-inflammatory drugs, or NSAIDs, which include aspirin, ibuprofen, and naproxen, as well as a variety of other nonprescription and prescription drugs, can decrease an individual's risk of developing some types of cancer. Sigrún Alba Jóhannesdóttir, BSc, of Aarhus University Hospital in Denmark, and her colleagues looked to see if the medications might decrease the risk of the three major types of skin cancer: basal cell carcinoma, squamous cell carcinoma, and malignant melanoma.The researchers analyzed medical records from northern Denmark from 1991 through 2009 and identified 1,974 diagnoses of squamous cell carcinoma, 13,316 diagnoses of basal cell carcinoma, and 3,242 diagnoses of malignant melanoma. They compared information, including prescription data, from these patients with information from 178,655 individuals without skin cancer.