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BJC:CpG岛甲基化表型与CRC预后无关

2016-11-12 MedSci MedSci原创

之前的研究已经表明,CpG岛甲基化表型(CIMP)对结直肠癌(CRC)的预后有不利影响。。然而,样本往往是有限的,只有少数的研究能够调整相关分子特征与分布。本研究的目的是,探讨大型人群研究中CIMP对CRC生存的影响。 研究纳入2003-2010年诊断的1385例CRC患者,分析CIMP状态和其他分子肿瘤的特点。中位数随访时间4.9年。 CIMP-H更常见于年龄更大、女性、近端结肠癌、

之前的研究已经表明,CpG岛甲基化表型(CIMP)对结直肠癌(CRC)的预后有不利影响。然而,样本往往是有限的,只有少数的研究能够调整相关分子特征与分布。本研究的目的是,探讨大型人群研究中CIMP对CRC生存的影响。

研究纳入2003-2010年诊断的1385例CRC患者,分析CIMP状态和其他分子肿瘤的特点。中位数随访时间4.9年。

CIMP-H更常见于年龄更大、女性、近端结肠癌、BRAF基因突变和MSI-H患者中。

然而,CIMP状态与CRC患者(总生存率:HR=1.00; 95% CI=0.72–1.40;疾病特异性生存率:HR=0.96; 95% CI=0.65–1.41)或其他亚组患者的预后无关。

虽然CIMP状态与MSI-H和BRAF突变存在相关性,不过MSI-H (HR=0.49; 95% CI=0.27–0.90)和BRAF突变(HR=1.78; 95% CI=1.10–2.84)对预后的影响是独立于CIMP状态的。

不管是CIMP-低/阴性组,还是CIMP-高组,化疗对CRC患者的预后有类似的好处。

调整其他重要的临床因素和相关基因突变后,CpG岛甲基化表型与CRC预后无关。

原始出处:

Min Jia1, Lina Jansen1, Viola Walter1, Katrin Tagscherer2,3, Wilfried Roth.No association of CpG island methylator phenotype and colorectal cancer survival: population-based study.British Journal of Cancer advance online publication 3 November 2016

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    2017-01-15 yxch36
  2. [GetPortalCommentsPageByObjectIdResponse(id=1827236, encodeId=a12b182e23623, content=<a href='/topic/show?id=52e95194b9' target=_blank style='color:#2F92EE;'>#CRC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5194, encryptionId=52e95194b9, topicName=CRC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Jan 15 20:54:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783798, encodeId=90de1e8379837, content=<a href='/topic/show?id=6413516394' target=_blank style='color:#2F92EE;'>#CpG岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5163, encryptionId=6413516394, topicName=CpG岛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sun Jul 16 23:54:00 CST 2017, time=2017-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535117, encodeId=c9bd153511e0c, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Mon Nov 14 12:54:00 CST 2016, time=2016-11-14, status=1, ipAttribution=)]
    2017-07-16 dingxiaobo
  3. [GetPortalCommentsPageByObjectIdResponse(id=1827236, encodeId=a12b182e23623, content=<a href='/topic/show?id=52e95194b9' target=_blank style='color:#2F92EE;'>#CRC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5194, encryptionId=52e95194b9, topicName=CRC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Sun Jan 15 20:54:00 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1783798, encodeId=90de1e8379837, content=<a href='/topic/show?id=6413516394' target=_blank style='color:#2F92EE;'>#CpG岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5163, encryptionId=6413516394, topicName=CpG岛)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=930e243, createdName=dingxiaobo, createdTime=Sun Jul 16 23:54:00 CST 2017, time=2017-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535117, encodeId=c9bd153511e0c, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Mon Nov 14 12:54:00 CST 2016, time=2016-11-14, status=1, ipAttribution=)]
    2016-11-14 tastas

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