Oncogene：抑癌基因Sprouty2双面功能，也可能促进结直肠癌转移

2016-01-08 MedSci译 MedSci原创

图片来源：medicalxpress.com 近日，来自美国密苏里大学医学院的研究人员通过研究发现，一种可以抑制多种癌症生长和扩散的基因或许可以促进某些结直肠癌的生长和扩散，相关研究刊登于国际杂志Oncogene上，该研究为后期开发治疗结直肠癌的新疗法提供了新的思路和希望。文章中，研究人员Sharad Khare说道，这种基因名为Sprouty2，此前该基因被认为可以帮助抵御癌症转移或癌

图片来源：medicalxpress.com

近日，来自美国密苏里大学医学院的研究人员通过研究发现，一种可以抑制多种癌症生长和扩散的基因或许可以促进某些结直肠癌的生长和扩散，相关研究刊登于国际杂志Oncogene上，该研究为后期开发治疗结直肠癌的新疗法提供了新的思路和希望。

文章中，研究人员Sharad Khare说道，这种基因名为Sprouty2，此前该基因被认为可以帮助抵御癌症转移或癌症向机体其它部位转移，比如乳腺癌、前列腺癌及肝癌等；然而最新的分子生物学研究结果表明，基因Sprouty2实际上可以帮助促进结直肠癌的转移。

研究人员在癌症细胞模型、小鼠模型及人类或组织样本中对Sprouty2基因进行了超过三年的研究，利用不同的分子生物学方法，研究者发现，相比其它类型的癌症而言，结直肠癌中的Sprouty2基因功能与前者并不相同，该基因被认为可以阻断特殊的分子回路从而抑制癌细胞生长及扩散；然而在结直肠癌中研究者发现，Sprouty2基因或许会增加癌细胞的转移特性，而他们认为这种现象或许是在Sprouty2基因北上调时候才会出现的。

结直肠癌引发的癌症死亡主要是因为肿瘤的复发及癌症转移到其它器官中，据美国癌症协会数据显示，在美国除了皮肤癌以外，结直肠癌是引发男性和女性因癌症死亡的第三大癌症，据估计个人患结直肠癌的终生风险是二十分之一。研究人员Khare说道，本文研究对于理解结直肠癌的转移提供了很好的线索，但我们认为这种现象的发生或许仅会在一小群的结直肠癌患者中发生，但我们并不知道发生这种现象的原因，后期我们将进一步研究确定Sprouty2基因的上调和结直肠癌患者的预期寿命之间的关联。

未来研究人员希望进行更多的深入研究来帮助理解为何某些患者处于较高的患病风险，以便最终开发出新型的个体化疗法来靶向作用Sprouty2基因，治疗结直肠癌患者。

最新一项在肺癌中研究发现，Sprouty2不同的剪接方式，产生的基因功能存在完全不同的差异。这一特点，可能为肿瘤治疗带来新的机会。

原始出处：

Zhang Q, Wei T, Shim K, Wright K, Xu K, Palka-Hamblin HL, Jurkevich A, Khare S.Atypical role of sprouty in colorectal cancer: sprouty repression inhibits epithelial-mesenchymal transition.Oncogene. 2015 Oct 5. doi: 10.1038/onc.2015.365

Kral R, Doriguzzi A, Mayer CE, Krenbek D, Setinek U, Sutterlüty-Fall H.Differential Effects of Variations at Codon 106 on Sprouty2 Functions in Lung Cancer-Derived Cells. J Cell Biochem. 2016 Jan 5. doi: 10.1002/jcb.25482.

Masoumi-Moghaddam S, Amini A, Wei AQ, Robertson G, Morris DL.Sprouty2 protein in prediction of post-treatment ascites in epithelial ovarian cancer treated with adjuvant carbotaxol chemotherapy. Am J Cancer Res. 2015 Jul 15;5(8):2498-507.

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2016-05-27 cy0324

#Gene#

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2016-04-30 jingyanzhu715_39486108

#抑癌#

0 0
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2016-01-10 12498484m46(暂无昵称)

#抑癌基因#

110 0
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2016-01-10 zhucaizhong7766

#癌基因#

86 0
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2016-01-10 crystal0564

#结直肠#

124 0
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2016-01-10 zsyan

#Oncogene#

72 0
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2016-01-10 linagood

#癌转移#

89 0
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2016-01-10 sunylz

#PRO#

82 0

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Oncogene：抑癌基因Sprouty2双面功能，也可能促进结直肠癌转移

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