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Nat Commun:新型纳米颗粒可促进癌症药物治疗的效果

2016-09-20 佚名 生物谷

(图片摘自www.sciencealert.com) 研究者们第一次发现类似于鱼竿或蠕虫的纳米颗粒相比梭型的纳米颗粒能够更加有效地穿透细胞或者类似于细胞核的特殊屏障。 这对于药物的运输系统来说是十分重大的突破。在癌症的药物治疗领域,研究者们不得不面对的一个问题就是如何将药物精确地运送到靶点部位。 该团队使用了一种新型的荧光显微技术,这一技术使得他们能够实时追踪



(图片摘自www.sciencealert.com)
研究者们第一次发现类似于鱼竿或蠕虫的纳米颗粒相比梭型的纳米颗粒能够更加有效地穿透细胞或者类似于细胞核的特殊屏障。

这对于药物的运输系统来说是十分重大的突破。在癌症的药物治疗领域,研究者们不得不面对的一个问题就是如何将药物精确地运送到靶点部位。

该团队使用了一种新型的荧光显微技术,这一技术使得他们能够实时追踪不同形状的纳米颗粒在单个癌症细胞中的运动。

之后,他们能够精确地定位药物释放的位点,以及如何在细胞中扩散。

"我们需要知道药物是如何到达最终的目的地",研究者之一Hinde博士说道:"而我们如今有了可以追踪这一奇妙过程的工具。另一方面,其它研究者们也能够利用该技术去追踪纳米颗粒或者药物运输系统"。

"他们将能够看到纳米颗粒到达细胞核或其它细胞结构的方式以及装卸货物的具体细节,这在之前是无法达到的"。

不过,我们需要首先讨论一下纳米颗粒。纳米颗粒是直径在1到100纳米之间的颗粒物质,他们最近被越来越频繁地用于运送药物到机体的指定部位,杀伤癌细胞以及帮助研究者们对整个机体进行系统的成像。

然而,问题在于纳米颗粒并不是完美的。尽管目前很多纳米颗粒技术十分有前景,但由于很多癌细胞紧密地压缩在一起,因此存在无法精确制导的问题。

Hinde研究组检测了4种不同形状的纳米颗粒:胶团状与囊泡状(这两种都是椭圆状的);以及鱼竿状与蠕虫状。

当研究者们利用不同的纳米颗粒运送doxorubicin(一类癌症药物)时,发现鱼竿型与蠕虫型的颗粒在进入细胞时不会遇到任何问题,但椭圆状的纳米颗粒则难以进入任何细胞核中。

而进入核膜对杀伤癌细胞来说又至关重要。因此鱼竿型与蠕虫型的纳米颗粒能够成为首选。

"癌细胞与健康细胞的奶不结构是截然不同的"。

"我们我们能够精确调控这些鱼竿型纳米颗粒的三维结构,那么它们将能够特异性地进入癌化的细胞内部,从而降低化疗的副效应"。

相关结果发表在最近一期的《nature Nanotechnology》杂志上。

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    2017-07-02 liye789132251
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    2016-11-04 liuli5079
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    2016-09-21 maymoon1983

    厉害啊 学习了

    0

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    2016-09-20 知难而进

    谢谢分享!

    0

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    2016-09-20 知难而进

    继续关注!

    0

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    2016-09-20 知难而进

    不同的纳米颗粒运送doxorubicin(一类癌症药物)时,发现鱼竿型与蠕虫型的颗粒在进入细胞时不会遇到任何问题,但椭圆状的纳米颗粒则难以进入任何细胞核中。

    0

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