J Endod：血管内皮生长因子与骨形成蛋白2对人牙髓干细胞成骨/成牙本质分化的并用效果研究

2017-05-04 lishiting MedSci原创

这篇研究的目的是为了评估协同并用血管内皮生长因子（VEGF）与骨形成蛋白2（BMP-2）是否可以增强体外培养的人牙髓干细胞（DPSCs）的成骨/成牙本质分化。

这篇研究的目的是为了评估协同并用血管内皮生长因子（VEGF）与骨形成蛋白2（BMP-2）是否可以增强体外培养的人牙髓干细胞（DPSCs）的成骨/成牙本质分化。

成骨/成牙本质分化培养基（OM）或生长培养基体外培养DPSCs，并施加不同浓度的VEGF和/或BMP-2刺激21天。茜素红染色（ARS）观察细胞矿化形成情况。不同浓度的VEGF和BMP-2协同并用，向DPSCs施加刺激21天。实验分组：组1：OM；组2：OM+VEGF；组3：OM+BMP-2；组4：OM+VEGF+BMP-2（亚组：组4a：VEGF刺激最初的7天，组4b：BMP-2刺激最后的14天，组4c：VEGF+BMP-2刺激21天）。随后，细胞进行定量ARS分析，或收集细胞进行定量聚合酶链式反应，观察核心结合因子α1（CBFA1）、碱性磷酸酶（ALP）和牙本质基质蛋白1（DMP-1）的表达改变。

结果显示，在未进行OM培养下，VEGF和/或BMP-2均无法诱导DPSCs的矿化形成。与OM相比，OM+VEGF可以诱导更多的矿化形成(P < .05)，而不是OM+BMP-2。在共同施加刺激的分组中，OM+VEGF组和组4a的诱导矿化能力最强，要明显优于OM组或其他组(P < .05)。定量聚合酶链式反应结果显示，组2、3和4a的CBFA1、ALP和DMP-1表达水平要明显高于组4b和4c(P < .05)。而ALP的表达水平只有组4a明显高于OM组(P < .05)。另外，3种基因的表达在组2和组3之间未见明显差异(P > .05)。

结论：在矿化诱导早期施加VEGF刺激能够增强DPSCs的成骨/成牙本质分化，而不是持续向DPSCs施加VEGF和BMP-2的共同刺激。

原始出处：

Aksel H， Huang GT. Combined Effects of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein 2 on Odonto/Osteogenic Differentiation of Human Dental Pulp Stem Cells In Vitro. J Endod. 2017 Apr 27. pii： S0099-2399(17)30151-6. doi： 10.1016/j.joen.2017.01.036.

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2017-12-06 jxrzshh

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2017-05-06 zhaojie88

#成骨#

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2017-05-06 ms8538335253054589

#牙本质#

69 0
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2017-05-06 仁医06

#生长因子#

61 0
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2017-05-06 ms6519009802973839

#牙髓干细胞#

67 0
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2017-05-06 qilu_qi

#血管内皮生长因子#

61 0
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2017-05-04 ayl3691

学习了

112 0
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2017-05-04 三生有幸9135

学习一下谢谢分享

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