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重磅:诺奖得主干细胞技术落地,斩获2.25亿美元巨额融资

2016-12-13 奇点网 应雨妍 奇点网 应雨妍

就在昨天,史上最大数额的A轮融资之一——2.25亿美元,花落BlueRock Therapeutics,由拜耳和Versant Ventures共同出资。这家创业公司,被他们的投资人称为“新一代再生医药公司”,他们的目标是开发“超一流”的诱导性多能干细胞(iPSCs)疗法,治愈多种疾病[1]!

就在昨天,史上最大数额的A轮融资之一——2.25亿美元,花落BlueRock Therapeutics,由拜耳和Versant Ventures共同出资。这家创业公司,被他们的投资人称为“新一代再生医药公司”,他们的目标是开发“超一流”的诱导性多能干细胞(iPSCs)疗法,治愈多种疾病[1]!


为什么BlueRock能够获得如此巨额的投资?原因之一在于他们的技术!BlueRock获得了山中伸弥教授独家专利——诱导性多能干细胞(iPSCs)技术的授权,这个技术有多重要呢?山中教授因为它在2012年获得了诺贝尔生理学和医学奖,在今年,世界顶级期刊《自然》和《细胞》还分别撰文纪念了iPSCs技术发明的第一个10年。(诱导性多功能干细胞(iPSCs)十年记:改变世界的伟大技术 | 奇点猛科技)  

这项技术被称为“改变世界的伟大技术”,研究人员可以用一个人的皮肤细胞、血细胞或者其他细胞进行重新编码,将它们转化为iPSCs,进而分化为干细胞、神经细胞或是其他任何需要再生的细胞。这种个性化的疾病治疗方法不仅可以规避免疫排斥的风险,还能避免使用胚胎干细胞带来的伦理方面的争议。


而10年的时间里, iPSCs的临床试验仅在2014年在日本进行了一例,虽然接受治疗的黄斑病患者成功地重见了光明,但是由于两个微小的基因突变,实验在2015年还是不幸被叫停了。尽管如此,这在当时的学术界还是“掀起了滔天大浪”,许多科学家都从这个技术和治疗中看到了巨大的希望。  

显然,生物科技界的许多投资机构也是这样想的,拜耳生命科学中心(BLSC)的研究带头人Axel Bouchon博士说“iPSCs技术具有成功解决一些最富挑战性疾病的潜力,我们知道,将它完全的施展开需要时间,需要克服许多障碍。但是,我们选择了全球范围内最优秀的人才和资源,我相信我们能够达到治愈疾病的最终目标。”  

Bouchon博士之所以有这样的信心,当然也和BlueRock的团队有着密不可分的关系。目前,BlueRock的目标之一是对患有心肌梗塞或是慢性心脏衰竭的患者进行治疗,帮助他们再生心肌细胞,让心脏能够重新“强有力地收缩和跳动”。这个项目由团队的两位创始人负责,一位是Gordon Keller博士,他是干细胞领域首屈一指的领军人物;另一位Michael A. Laflamme博士,是心脏细胞治疗界的“先驱”。参与投资的Versant Ventures公司透露,BlueRock的临床试验将会在2018年开始。


Gordon Keller博士(左)和Michael A. Laflamme博士(右)  

另外,他们还邀请到了纪念斯隆-凯特琳癌症中心(MemorialSloan-Kettering Cancer Center)的Lorenz Studer博士做他们的科学联合创始人。Studer博士也是一位“大牛”,他是2015年“麦克阿瑟天才奖”的得主,他曾经在《自然》杂志上发表文章,利用诱导性多能干细胞分化出了可以产生多巴胺的神经元,治好了患帕金森病的小鼠[2],这个研究的另一位通讯作者 Viviane Tabar医生也是 BlueRock的科学联合创始人。

Lorenz Studer博士  

研发工作将在多伦多、纽约和波士顿进行。除了公司自己的人才外,他们还会和波士顿的CCRM公司开展合作,CCRM在对再生医学技术的开发和商业化上都有丰富的经验,对 BlueRock的研发工作和未来的市场化都会有很大的帮助。  

干细胞疗法在近年来飞速发展,但是也遭遇了不少挫折,例如最近的BioCardia,因为缺乏资金,它放弃了融资5000万美元IPO的计划[3]。拜耳的投资团队显然也注意到了资金问题,因此他们给出的2.25亿投资足够支撑BlueRock四年内的研发经费。在这样的现状下,我们也期望着BlueRock的进入能为这个领域注入新的血液,打开新的局面。  

原始出处:



[3] Ben Adams.Stem cell biotech BioCardia drops $50M IPO.Fierce Biotech. Apr 18, 2016. 

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    2016-12-15 zhao4618
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    2016-12-15 wumeihua90
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    2016-12-15 xxxx1054
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    2016-12-13 䖝二

    听起来比较靠谱

    0

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