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BMC Musculoskelet Disord:甲状旁腺激素激活的磷脂酶C信号传导可介导快速破骨细胞生成

2018-09-02 MedSci MedSci原创

与年龄相关的骨质疏松症的发生风险越来越大,严重威胁着老年人的生活质量。人甲状旁腺激素(hPTH)成功应用于骨质疏松症的治疗,但其机制,尤其是PTH愈合骨折中激活的信号通路尚不清楚。hPTH(1-34)和GR(1-34)(PLC缺乏类似物)每天一次注射到具有骨折的睾丸切除的雄性小鼠中,在骨折后第二天开始并持续4周。为了探索磷脂酶C信号通路在雄激素缺乏性骨折愈合中的作用,通过X线,显微CT,生物力学测

与年龄相关的骨质疏松症的发生风险越来越大,严重威胁着老年人的生活质量。人甲状旁腺激素(hPTH)成功应用于骨质疏松症的治疗,但其机制,尤其是PTH愈合骨折中激活的信号通路尚不清楚。

hPTH(1-34)和GR(1-34)(PLC缺乏类似物)每天一次注射到具有骨折的睾丸切除的雄性小鼠中,在骨折后第二天开始并持续4周。为了探索磷脂酶C信号通路在雄激素缺乏性骨折愈合中的作用,通过X线,显微CT,生物力学测试,血清生物化学,骨髓细胞培养和基因表达定量评估骨折愈合。

结果显示,骨折两周后,两种肽均显著增加愈合区域的骨矿物质密度(BMD)、骨量含量(BMC)和骨量(BV/TV)。然而,与hPTH(1-34)相比,GR(1-34)诱导更多的编织骨,更高的BMC和BMD,以及更少的血清TRAP和破骨细胞。治疗4周后,hPTH(1-34)对骨折愈合的影响与GR(1-34)无明显差异。与hPTH(1-34)相比,GR(1-34)在给药后立即在离体条件下诱导相似的成骨作用但较少破骨细胞生成,GR(1-34)治疗中RANKL,NFATC1,TRAP和组织蛋白酶K的较弱活化来证实。

综上所述,这些结果表明,间歇注射hPTH(1-34)激活的PLC信号通过快速激活骨折愈合区中的破骨细胞生成而导致骨吸收。

原始出处:


Li W, Yuan L, et al., Phospholipase C signaling activated by parathyroid hormone mediates the rapid osteoclastogenesis in the fracture healing of orchiectomized mice. BMC Musculoskelet Disord. 2018 Aug 29;19(1):311. doi: 10.1186/s12891-018-2231-3.

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    2019-05-31 cmsvly
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2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342255, encodeId=ac1b34225576, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Sep 02 09:37:25 CST 2018, time=2018-09-02, status=1, ipAttribution=)]
    2018-09-06 一天没事干

    很好的学习机会

    0

  5. 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2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342255, encodeId=ac1b34225576, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Sep 02 09:37:25 CST 2018, time=2018-09-02, status=1, ipAttribution=)]
    2018-09-03 1ddf0692m34(暂无匿称)

    学习了谢谢分享

    0

  6. 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  7. 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2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342255, encodeId=ac1b34225576, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Sep 02 09:37:25 CST 2018, time=2018-09-02, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1974846, encodeId=f4d019e48467b, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Thu Mar 14 11:03:00 CST 2019, time=2019-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012787, encodeId=52b52012e87ba, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], 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  9. 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encodeId=1005149506ec4, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Mon Sep 03 16:03:00 CST 2018, time=2018-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342264, encodeId=bc483422648a, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sun Sep 02 09:49:18 CST 2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342255, encodeId=ac1b34225576, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Sep 02 09:37:25 CST 2018, time=2018-09-02, status=1, ipAttribution=)]
    2018-09-02 kafei

    学习了谢谢

    0

  10. 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encodeId=1005149506ec4, content=<a href='/topic/show?id=3c0b10182102' target=_blank style='color:#2F92EE;'>#骨细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101821, encryptionId=3c0b10182102, topicName=骨细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=723c9147696, createdName=jj000004, createdTime=Mon Sep 03 16:03:00 CST 2018, time=2018-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342264, encodeId=bc483422648a, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, createdBy=8bff2327056, createdName=kafei, createdTime=Sun Sep 02 09:49:18 CST 2018, time=2018-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=342255, encodeId=ac1b34225576, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Sep 02 09:37:25 CST 2018, time=2018-09-02, status=1, ipAttribution=)]
    2018-09-02 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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