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NEJM:研究性新药mAb114和REGN-EB3降低了埃博拉病毒所致的死亡风险

2019-11-28 Allan MedSci原创

根据在刚果民主共和国(DRC)进行的一项临床试验的结果,与ZMapp相比,研究性治疗药物mAb114和REGN-EB3降低了埃博拉病毒所致的死亡风险。

埃博拉病毒是丝状病毒科的其中一种病毒,可导致埃博拉出血热,包含数种不同程度的症状(包括恶心、呕吐、腹泻、肤色改变、全身酸痛、体内出血、体外出血、发烧等),感染者症状与同为纤维病毒科的马尔堡病毒极为相似。具有50%90%的致死率,致死原因主要为中风、心肌梗塞、低血容量性休克或器官衰竭。

根据在刚果民主共和国(DRC)进行的一项临床试验的结果,与ZMapp相比,研究性治疗药物mAb114REGN-EB3降低了埃博拉病毒所致的死亡风险。2019812日发布的公告指出,研究者根据独立数据和安全监控委员会基于对499名研究患者的初步数据的审查,于201989日提前中止了试验。初步分析发现,mAb114REGN-EB3的性能均优于ZMapp


原始出处:

https://www.firstwordpharma.com/node/1683957?tsid=4

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    2020-03-26 snf701207
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    2019-11-28 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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阳性结果促使埃博拉临床试验提前停止

Regeneron的REGN-EB3治疗在预防埃博拉死亡方面优于ZMapp,因此提前停止了埃博拉的临床试验。基于之前的PREVAIL II临床试验,ZMapp作为标准护理方法设为试验的对照组。在审查了499名患者的临时死亡率数据后,独立数据安全监测委员会决定提前停止试验PALM试验。

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