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Thorax:肺癌后第二原发癌和更高级吸烟相关原发癌的发病率

2019-02-19 xiangting MedSci原创

从初次诊断开始,肺癌幸存者后续肺癌、喉癌、头颈癌和食管鳞状细胞癌发病率升高至少持续10年。

15年间肺癌的5年生存率翻了一番。虽然人们已经认识到了第二原发癌的风险,但仍缺乏随时间量化的改变。这项研究描述了肺癌幸存者中第二和更高级吸烟相关原发癌的发病率,并确定了高发病率组以及首次诊断后发病率是如何随时间变化的。

从英国公共卫生署国家癌症登记和分析中心获得2000年至2014年英国诊断的吸烟相关原发癌数据(肺癌、喉癌、头颈癌、食管鳞癌和膀胱癌)。研究人员使用泊松回归,针对整体和不同亚组,计算了从肺癌最初诊断开始长达10年间第二原发癌的绝对发病率和标准化发病率比率。

初诊年龄50和79岁的特高危患者吸烟相关第二原发癌的发病率从肺癌初次诊断开始持续升高至少10年。尽管标准化发病率比率最高的是食管鳞状细胞癌(2.4)和喉癌(2.8),最常见的第二恶性肿瘤类型是肺癌,并且女性发病率持续高于男性。过去十年间,第二原发肺癌的发病率翻了一番。

从初次诊断开始,肺癌幸存者后续肺癌、喉癌、头颈癌和食管鳞状细胞癌发病率升高至少持续10年。对极高危患者应考虑将常规随访从5年增至10年,同时监测其他的吸烟相关癌症。

原始出处:

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1823533, encodeId=0c4f1823533e4, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Thu Dec 19 01:17:00 CST 2019, time=2019-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=361271, encodeId=979e3612e1f3, content=学习学习努力学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Fri Feb 22 15:22:23 CST 2019, time=2019-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=361002, encodeId=0e9b36100234, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Tue Feb 19 12:48:32 CST 2019, time=2019-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=360999, encodeId=8ce736099973, content=好文章,点赞啦!认真学习,谢谢分享给广大同好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Tue Feb 19 12:03:51 CST 2019, time=2019-02-19, status=1, ipAttribution=)]
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    2019-02-19 一个字-牛

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