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Brit J Cancer：女性超重、体重增加与肥胖相关的癌症风险

2018-09-11 xing.T MedSci原创

超重体重增加肥胖相关的癌症风险
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由此可见，在中年维持稳定的体重，不论基线时的BMI如何，以及避免超重，对于预防女性几种与肥胖相关的癌症都很重要。研究人员首次发现了体重增加中等和较快的女性患胰腺癌的风险增加。

据报道，超重和体重增加会独立增加几种癌症的风险。很少有在全国代表性女性人群中进行的发表研究旨在探究特定的“肥胖相关”癌症与之前体重变化和相关的混杂因素的关系。

近日，肿瘤领域权威杂志British Journal of Cancer上发表了一篇研究文章，基于自我报告的人体测量学指标，研究人员前瞻性地评估了挪威妇女和癌症研究中受试者的体重指数（BMI）、6年内体重变化以及随后的肥胖相关癌症风险。研究人员使用Cox比例风险模型计算了风险比，并采用受限制的三次样条以模拟潜在的非线性剂量-反应关系。

研究人员发现超重增加了整体肥胖相关癌症、绝经后乳腺癌、结肠直肠癌、结肠癌、子宫内膜癌和肾癌的风险，子宫内膜癌的风险增加了三倍。体重增加较快（≥10kg）会导致整体肥胖相关癌症、绝经后乳腺癌、子宫内膜癌和胰腺癌风险增加。较快的体重增加与胰腺癌之间的关联性很强，风险增加了91％。

由此可见，在中年维持稳定的体重，不论基线时的BMI如何，以及避免超重，对于预防女性几种与肥胖相关的癌症都很重要。研究人员首次发现了体重增加中等和较快的女性患胰腺癌的风险增加。

原始出处：

Marisa da Silva,et al.Excess body weight, weight gain and obesity-related cancer risk in women in Norway: the Norwegian Women and Cancer study.British Journal of Cancer. 2018.https://www.nature.com/articles/s41416-018-0240-5

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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298228, encodeId=4170129822894, content=<a href='/topic/show?id=3379266918f' target=_blank style='color:#2F92EE;'>#体重增加#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26691, encryptionId=3379266918f, topicName=体重增加)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Thu Sep 13 07:51:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344756, encodeId=bb65344e56e0, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, 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    2019-08-25 jambiya

    #肥胖相关的癌症#

    0

  2. 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    2018-10-17 zwjnj2

    好好学习天天向上

    0

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    2018-09-26 衣带渐宽

    学习

    0

  4. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298228, encodeId=4170129822894, content=<a href='/topic/show?id=3379266918f' target=_blank style='color:#2F92EE;'>#体重增加#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26691, encryptionId=3379266918f, topicName=体重增加)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Thu Sep 13 07:51:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344756, encodeId=bb65344e56e0, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, 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    2018-09-20 123cdd9bm46暂无昵称

    了解

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298228, encodeId=4170129822894, content=<a href='/topic/show?id=3379266918f' target=_blank style='color:#2F92EE;'>#体重增加#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26691, encryptionId=3379266918f, topicName=体重增加)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Thu Sep 13 07:51:00 CST 2018, time=2018-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344756, encodeId=bb65344e56e0, content=学习了谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLbTp9nZtjwVrSZNxAXbAicnKQWnic2eBdJUQYhxO36XdkstSicr7FVF8p5ReH4omtmsbnLdvZLiaJJ1A/132, 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    2018-09-17 zwjnj2

    好好学习天天学习认真的学习

    0

  6. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Sep 12 18:24:42 CST 2018, time=2018-09-12, status=1, ipAttribution=)]
    2018-09-13 phoebeyan520

    学习了

    0

  7. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Sep 12 18:24:42 CST 2018, time=2018-09-12, status=1, ipAttribution=)]
    2018-09-13 839640778

    #体重增加#

    0

  8. 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    2018-09-13 kafei

    学习了谢谢

    0

  9. 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    2018-09-12 惠映实验室

    学习了，谢谢分享。

    0

  10. 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createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/02/7354b3539aae6a0ccb1e0fff04c12084.jpg, createdBy=205b1984786, createdName=随梦飞扬, createdTime=Wed Sep 12 18:24:42 CST 2018, time=2018-09-12, status=1, ipAttribution=)]
    2018-09-12 随梦飞扬

    研究人员首次发现了体重增加中等和较快的女性患胰腺癌的风险增加。

    0

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在高BMI的RA患者中，与超声相比，临床评估的SJC和DAS28都被低估了。

BMJ：低BMI导致的营养不良及贫血风险远低于高BMI导致的超重及肥胖风险

研究认为，低体重指数与贫血和严重贫血的相关性较高体重指数与超重和肥胖的相关性相比要弱得多

Clin Exp Rheumatol：超重和肥胖影响类风湿性关节炎滑膜炎的临床评估

与超声相比，高BMI类风湿性关节炎患者的SJC和DAS28均被临床评价低估了。

J Hypertens：尿酸与超重和肥胖青少年心血管代谢危险因素相关!

由此可见，该研究发现尿酸与血压、胰岛素和甘油三酯呈正相关。随着尿酸水平的增加，代谢危险因素有所聚集，而血压升高是不常出现的危险因素。进一步的研究需要评估尿酸和心血管代谢危险因素之间的联系。

病例分享：体型超重的初发2型糖尿病，胰岛功能保护至关重要！

患者，男，28岁。主诉：反复烦渴多饮1周，加重伴乏力3天。

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