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Sci Rep:前列腺癌细胞的高通量、时间分别率力学表型分析

2019-04-20 AlexYang MedSci原创

世界范围内,前列腺癌是仅次于肺癌的男性诊断疾病。甚至是最好的诊断标准仍旧缺乏精度,导致组织检测的假阳性从而导致患者接受不必要的外科手术干预。明确的早期诊断工具的缺乏是一个很明显的问题。最近,有研究人员呈现了微流体平台,时间分辨流体力学拉伸器(TR-HS),该设备可以允许每秒内对上千个细胞的非破坏性应力进行动态的力学响应调查。TR-HS整合了高速成像和计算机视觉,从而实现悬浮于液体中单个细胞的自动化

世界范围内,前列腺癌是仅次于肺癌的男性诊断疾病。甚至是最好的诊断标准仍旧缺乏精度,导致组织检测的假阳性从而导致患者接受不必要的外科手术干预。明确的早期诊断工具的缺乏是一个很明显的问题。

最近,有研究人员呈现了微流体平台,时间分辨流体力学拉伸器(TR-HS),该设备可以允许每秒内对上千个细胞的非破坏性应力进行动态的力学响应调查。TR-HS整合了高速成像和计算机视觉,从而实现悬浮于液体中单个细胞的自动化检测和追踪,并基于它们的力学特性进行细胞分类。研究人员阐释了基于全细胞、时间分辨率的对水动力载荷的响应在健康和癌症前列腺细胞间的区分方法。另外,研究人员还进行了一个有限单元法(FEM)模型来鉴定他们设备中的对细胞变形的力学响应。最后,研究人员报道了对2种不同的细胞的分类情况。

最后,研究人员指出,他们的研究介绍了一种高通量评估细胞悬液的方法,并且在创新诊断设备的发展中代表了一种可行的方案。

原始出处:

Yuri Belotti, Serenella Tolomeo, Michael J. Conneely et al. High-Throughput, Time-Resolved Mechanical Phenotyping of Prostate Cancer Cells. Sci Rep. 05 April 2019.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1969434, encodeId=f8c019694342b, content=<a href='/topic/show?id=6532102e6059' target=_blank style='color:#2F92EE;'>#高通量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102760, encryptionId=6532102e6059, topicName=高通量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ad7f282, createdName=yang0210, createdTime=Wed Oct 30 10:08:00 CST 2019, time=2019-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252592, encodeId=988d125259285, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon Apr 22 04:08:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535219, encodeId=fbed153521912, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Mon Apr 22 04:08:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1620251, encodeId=2827162025177, content=<a href='/topic/show?id=c62132549a5' target=_blank style='color:#2F92EE;'>#前列腺癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32549, encryptionId=c62132549a5, topicName=前列腺癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09820091072, createdName=lifestar, createdTime=Mon Apr 22 04:08:00 CST 2019, time=2019-04-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040439, encodeId=6ed71040439a4, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sat Apr 20 16:08:00 CST 2019, time=2019-04-20, status=1, ipAttribution=)]
    2019-04-22 yxch36
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    2019-04-22 tastas
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    2019-04-20 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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