PLoS ONE：GPx3酶有助预防心血管疾病

近日，明尼苏达医学院的研究人员与公共卫生学院合作发现一种酶，该酶在较高水平以及高密度脂蛋白（好胆固醇）水平低时，可以大大降低风险心血管疾病。

这种新发现的酶叫谷胱甘肽过氧化物酶或GPX3，是一种天然抗氧化剂，有助于保护生物体的氧化损伤，有助于机体的自然修复。研究人员发现“好”胆固醇水平高的患者之间，GPX3酶的水平并没有显着性差异。然而，“好”胆固醇水平低的患者，GPX3酶可能对疾病来说是一个益处。

这项最新研究刊登在PLoS One杂志上，新研究证实这种酶是一种天然抗氧化剂。

在研究中，科学家们发现高水平的GPX3酶伴随“好”胆固醇水平低的人都不太罹患心血管疾病，要整整低六倍。美国明尼苏达大学医学院药理学博士Jordan L. Holtzman教授说： GPx3抗氧化剂是对心脏健康有好处。”

Holtzman说：该酶对高密度脂蛋白胆固醇低的患者非常重要。研究人员认为有必要进一步开展研究来确定GPx3作用，进而找到可以提高其活性的药物。

doi:10.1371/journal.pone.0038901
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Low Serum Glutathione Peroxidase Activity Is Associated with Increased Cardiovascular Mortality in Individuals with Low HDLc’s

Brian Buijsse, Duk-Hee Lee, Lyn Steffen, Richard R. Erickson, Russell V. Luepker, David R. Jacobs Jr, Jordan L. Holtzman

Background

Since oxidized LDL is thought to initiate atherosclerosis and the serum glutathione peroxidase (GPx3) reduces oxidized lipids, we investigated whether high GPx3 activity reduces cardiovascular disease (CVD) mortality.

Methods

We determined GPx3 in stored samples from the Minnesota Heart Survey of 130 participants who after 5 to 12 years of follow-up had died of CVD and 240 controls. Participants were 26 to 85 years old and predominantly white. In a nested case-control, study we performed logistic regressions to calculate odds ratios (OR) adjusted for age, sex, baseline year, body mass index, smoking, alcohol intake, physical activity, total and HDL cholesterols, systolic blood pressure, serum glucose and gamma glutamyltransferase (GTT) activity. The referent was the quartile with the highest GPx3 activity (quartile 4).

Results

OR’s for CVD mortality for increasing quartiles of GPx3 were 2.37, 2.14, 1.83 and 1.00 (P for trend 0.02). This inverse correlation was confined to those with HDLc’s below the median (P for interaction, 0.006). The OR’s for increasing quartiles of GPx3 in this group were 6.08, 5.00, 3.64 and 1.00 (P for trend, 0.002).

Conclusions

Individuals with both low HDLc and GPx3 activity are at markedly increased risk for death from CVD.