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J Dent Res:口腔疾病与非酒精性脂肪肝之间的关系

2019-08-11 lishiting MedSci原创

在美国,非酒精性脂肪肝(NAFLD)的发生率为30.6%,并且还在不断上升。而NAFLD与牙周炎和龋齿拥有一些共同的风险因素。这篇研究的目的是通过对1988至1994年间的横截面及具有国家代表性的国家健康和营养检查调查(NHANES)数据进行分析来探讨美国NAFLD与几种口腔状态之间的联系。

在美国,非酒精性脂肪肝(NAFLD)的发生率为30.6%,并且还在不断上升。而NAFLD与牙周炎和龋齿拥有一些共同的风险因素。这篇研究的目的是通过对1988至1994年间的横截面及具有国家代表性的国家健康和营养检查调查(NHANES)数据进行分析来探讨美国NAFLD与几种口腔状态之间的联系。NAFLD采用超声检查进行评估(USON),筛选黄金标准在最近的NHANES中不可用,非侵袭性纤维化评分(FS), 脂肪肝指数(FLI)和美国脂肪肝指数(US-FLI)作为其他筛选条件。共有5,421名年龄在21至74岁之间的候选者完成了相关数据的调查,并且转铁蛋白水平≤50%,无乙型或丙型肝炎,也不是大量饮酒者。采用多变量模型检测中等-严重牙周炎、未治疗龋齿、有过龋齿经历和牙齿缺失(<20 teeth)对NAFLD的影响,同时控制临床、生物学和社会人口统计相关的因素。采用logistic回归计算95% CIs,加权评估计算比值比(ORs)。结果显示,基于标准分类,罹患NAFLD的成年人在17%至24%之间。在校正模型中,与那些口腔更健康的受试者相比,牙齿<20颗的成年人基于检测结果更有

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