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Am J Gastroenterol:青少年嗜酸细胞性食管炎患者食管扩张性变化

2017-05-20 zhangfan MedSci原创

青少年嗜酸细胞性食管炎患者发生食道重塑,在并发症发生前应尽早诊断并开展治疗

嗜酸细胞性食管炎(EoE)后遗症包括食物嵌塞和食管狭窄。目前炎症反应的持续时间是可预测的,但并发症仍然是不可预知。功能腔成像探针(FLIP)发现成人EoE的病人食道膨胀性降低。近日研究人员对青少年嗜酸细胞性食管炎对食管扩张性的影响因素进行了研究。

首先,受试者接受FLIP内镜检查以确定其是否患病,测量最大食管扩张压力为40mmHg时,食管的扩张情况。研究人员比较嗜酸细胞性食管炎患者与非患者之间食管扩张性的差异以及EoE患者之间的差异。

年龄在3-18岁的,共44名非EoE青少年以及88名患儿参与研究。在非EoE青少年中,年龄对食管性扩张有影响但EoE患者中未发现这一情况。研究发现,活跃性炎症、组织层固有纤维化以及纤维化表型的各种特征(狭窄,食物嵌塞以及环圈内镜检查)与EoE 患者食管扩张性降低有关。FLIP 检查是安全,可行的且耐受性良好。

研究认为,青少年嗜酸细胞性食管炎患者发生食道重塑,在并发症发生前应尽早诊断并开展治疗。

原始出处:


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    2017-12-06 智慧医人
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createdAvatar=null, createdBy=b8756488272, createdName=天堂的云, createdTime=Sun May 21 23:33:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200887, encodeId=98f820088eb9, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun May 21 14:05:12 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
    2018-03-06 lsj637
  5. 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createdAvatar=null, createdBy=b8756488272, createdName=天堂的云, createdTime=Sun May 21 23:33:00 CST 2017, time=2017-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200887, encodeId=98f820088eb9, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun May 21 14:05:12 CST 2017, time=2017-05-21, status=1, ipAttribution=)]
    2018-01-12 许安
  6. 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  7. 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    2017-05-21 zhouqu_8
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    2017-05-21 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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