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Cell子刊:这是长期熬夜增加癌症风险的因素之一?

2016-11-23 佚名 药明康德微信号

生物钟如何与肿瘤产生联系?最近,美国Scripps研究所(The Scripps Research Institute)的科学家发现,一种关键的生物钟调控蛋白CRY2与肿瘤发生之间可能有着密切关联,并提示,生物钟的打乱可能使得原癌蛋白c-MYC的水平处于失控状态。这一研究结果发表在了《细胞》子刊《Molecular Cell》上。“这对揭示生物钟和癌症之间的联系似乎有着重大的意义,”文章的通讯作者

生物钟如何与肿瘤产生联系?最近,美国Scripps研究所(The Scripps Research Institute)的科学家发现,一种关键的生物钟调控蛋白CRY2与肿瘤发生之间可能有着密切关联,并提示,生物钟的打乱可能使得原癌蛋白c-MYC的水平处于失控状态。这一研究结果发表在了《细胞》子刊《Molecular Cell》上。

“这对揭示生物钟和癌症之间的联系似乎有着重大的意义,”文章的通讯作者Katja A. Lamia教授说道:“大家早已意识到日夜节律与细胞增殖之间存在关联,但一直说不清这种关联到底是什么。”

▲文章的通讯作者Katja A. Lamia教授(图片来源:Scripps官网)

CRY2蛋白是一种转录抑制因子,在夜间的表达水平要显著高于白天,为维持正常的生物钟节律所必需。研究者发现了CRY2的一项全新的功能,即作为含有FBXL3蛋白的泛素连接酶E3复合物SCF的组分。CRY2可与T58位点被磷酸化的c-MYC结合,作为底物接头蛋白FBXL3的辅助因子,促使SCF复合物对c-MYC进行泛素化标记,以介导其降解。

▲CRY2对c-MYC作用机制(图片来源:《Molecular Cell》)

c-MYC是调节细胞增殖的关键蛋白,其T58位点又是重要的磷酸化降解决定子,且还是致癌突变发生的“热点”。当CRY2基因被敲除后,小鼠细胞对c-MYC的降解显著减弱,且细胞增殖大大加快,表现出类似癌细胞的特点。有趣的是,CRY2的同源蛋白——另一种关键的生物钟调控蛋白CRY1没有上述作用。

“生物钟蛋白的这种功能之前还从未被发现过,”文章的第一作者Anne-Laure Huber博士说道。研究者们认为,接下来的一项重要工作便是在人类组织中证实这一联系,而这可能就是长期上夜班和频繁倒时差增加患癌几率的原因之一。

原始出处:

Anne-Laure Huber,StephanieJ. Papp.CRY2 and FBXL3 Cooperatively Degrade c-MYC.molcel.2016.10.012

Wang X ,Cunningham M ,Zhang X ,Tokarz S ,Laraway B ,Troxell M .Phosphorylation regulates c-Myc's oncogenic activity in the mammary gland.

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    2017-02-27 小树熊

    学习了,谢谢,以后要拒绝熬夜

    0

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    2017-03-27 维他命
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    2016-11-24 gospel007

    作为医师,没有不熬夜的。

    0

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    2016-11-24 ylzr123

    一种关键的生物钟调控蛋白CRY2与肿瘤发生之间可能有着密切关联,并提示,生物钟的打乱可能使得原癌蛋白c-MYC的水平处于失控状态。

    0

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    2016-11-23 doctorJiangchao

    继续学习

    0

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    2016-11-23 Doc. Yang

    广大医学工作者很少不熬夜的

    0

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    2016-11-23 susice

    良好的生活习惯很重要!

    0

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