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ATVB:较低的HDL胆固醇水平与较高的外周血白细胞计数相关

2020-12-21 MedSci原创 MedSci原创

较低的HDL胆固醇水平与较高的外周血白细胞计数相关,包括淋巴细胞,单核细胞和嗜酸性粒细胞。

动物研究表明,高密度脂蛋白(HDL)可调节造血干细胞的增殖和分化。近日,血管领域权威杂志Arteriosclerosis, Thrombosis, and Vascular Biology上发表了一篇研究文章,该研究使用孟德尔随机方法评估了较低的HDL胆固醇是否与较高的白细胞计数相关。

研究人员纳入了哥本哈根普通人群研究中年龄在20至100岁之间的107952名参与者,包含了有关HDL胆固醇、白细胞计数以及与HDL胆固醇相关的9种遗传变异的信息。

在多变量调整的观察分析中,HDL胆固醇水平与白细胞计数呈负相关。对于连续变量,HDL胆固醇降低1 mmol/L(39 mg/dL)与白细胞增加5.1%(95%CI为4.7%–5.4%),中性粒细胞增加4.5%(95%CI为4.0%–4.9%),淋巴细胞增加5.7%(95%CI为5.3%–6.1%),单核细胞增加5.7%(95%CI为5.3%–6.2%),嗜酸性粒细胞增加14.8%(95%CI为13.9%–15.8%),嗜碱性粒细胞增加3.9%(95%CI为3.1%–4.7%)。在使用反方差加权分析进行年龄和性别校正的遗传分析中,遗传确定的HDL胆固醇降低1mmol/L(39 mg/dL)与白细胞增加2.2%(95%CI为0.3%–4.1%),淋巴细胞增加4.3%(95%CI为1.6%–7.1%),单核细胞增加4.3%(95%CI为2.6%–6.1%)和嗜酸性粒细胞增加4.8%(95%CI为1.2%–8.5%)相关。

由此可见,较低的HDL胆固醇水平与较高的外周血白细胞计数相关,包括淋巴细胞,单核细胞和嗜酸性粒细胞

原始出处:

Mads Harsløf.et al.Low HDL (High-Density Lipoprotein) Cholesterol and High White Blood Cell Counts A Mendelian Randomization Study.ATVB.2020.https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.314983

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createdBy=bfa61632044, createdName=锋行天下, createdTime=Wed Dec 23 00:40:19 CST 2020, time=2020-12-23, status=1, ipAttribution=)]
    2021-08-23 gongliu
  3. 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createdBy=bfa61632044, createdName=锋行天下, createdTime=Wed Dec 23 00:40:19 CST 2020, time=2020-12-23, status=1, ipAttribution=)]
    2020-12-30 viviansara

    值得参考的思路

    0

  4. 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topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910242, encodeId=dffc91024226, content=意义是?, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=090d49833, createdName=LaserDermatol, createdTime=Wed Dec 23 00:40:59 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910241, encodeId=eba8910241f2, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160325/IMG56F49530925803400.jpg, createdBy=bfa61632044, createdName=锋行天下, createdTime=Wed Dec 23 00:40:19 CST 2020, time=2020-12-23, status=1, ipAttribution=)]
    2020-12-27 chenxianglei

    胆固醇与白细胞的关系也可能是相互的

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910938, encodeId=699791093830, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/06/19/425bda35e83de63900d3afe3ba2e5cd0.jpg, createdBy=53612384207, createdName=1231cf9dm12暂无昵称, createdTime=Fri Dec 25 18:03:29 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316451, encodeId=f1dc13164515e, content=<a href='/topic/show?id=73f386080a' target=_blank style='color:#2F92EE;'>#HDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8608, encryptionId=73f386080a, topicName=HDL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416523, encodeId=c8e5141652362, content=<a href='/topic/show?id=166b861857' target=_blank style='color:#2F92EE;'>#HDL胆固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8618, encryptionId=166b861857, topicName=HDL胆固醇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ddb3195652, createdName=Eleven12, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578569, encodeId=5e6915e856993, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910242, encodeId=dffc91024226, content=意义是?, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=090d49833, createdName=LaserDermatol, createdTime=Wed Dec 23 00:40:59 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910241, encodeId=eba8910241f2, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160325/IMG56F49530925803400.jpg, createdBy=bfa61632044, createdName=锋行天下, createdTime=Wed Dec 23 00:40:19 CST 2020, time=2020-12-23, status=1, ipAttribution=)]
    2020-12-25 1231cf9dm12暂无昵称

    学习了

    0

  6. 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createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416523, encodeId=c8e5141652362, content=<a href='/topic/show?id=166b861857' target=_blank style='color:#2F92EE;'>#HDL胆固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8618, encryptionId=166b861857, topicName=HDL胆固醇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ddb3195652, createdName=Eleven12, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578569, encodeId=5e6915e856993, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910242, encodeId=dffc91024226, content=意义是?, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=090d49833, createdName=LaserDermatol, createdTime=Wed Dec 23 00:40:59 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910241, encodeId=eba8910241f2, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160325/IMG56F49530925803400.jpg, createdBy=bfa61632044, createdName=锋行天下, createdTime=Wed Dec 23 00:40:19 CST 2020, time=2020-12-23, status=1, ipAttribution=)]
    2020-12-23 医者仁心
  7. 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createdBy=bfa61632044, createdName=锋行天下, createdTime=Wed Dec 23 00:40:19 CST 2020, time=2020-12-23, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1951776, encodeId=3d411951e763f, content=<a href='/topic/show?id=6a53e17507d' target=_blank style='color:#2F92EE;'>#白细胞计数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71750, encryptionId=6a53e17507d, topicName=白细胞计数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8346212, createdName=respect, createdTime=Sun Dec 05 07:32:11 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977984, encodeId=f61e19e7984e5, content=<a href='/topic/show?id=20411e958de' target=_blank style='color:#2F92EE;'>#TVB#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17958, encryptionId=20411e958de, topicName=TVB)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910938, encodeId=699791093830, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/06/19/425bda35e83de63900d3afe3ba2e5cd0.jpg, createdBy=53612384207, createdName=1231cf9dm12暂无昵称, createdTime=Fri Dec 25 18:03:29 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316451, encodeId=f1dc13164515e, content=<a href='/topic/show?id=73f386080a' target=_blank style='color:#2F92EE;'>#HDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8608, encryptionId=73f386080a, topicName=HDL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416523, encodeId=c8e5141652362, content=<a href='/topic/show?id=166b861857' target=_blank style='color:#2F92EE;'>#HDL胆固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8618, encryptionId=166b861857, topicName=HDL胆固醇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ddb3195652, createdName=Eleven12, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578569, encodeId=5e6915e856993, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910242, encodeId=dffc91024226, content=意义是?, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=090d49833, createdName=LaserDermatol, createdTime=Wed Dec 23 00:40:59 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910241, encodeId=eba8910241f2, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160325/IMG56F49530925803400.jpg, createdBy=bfa61632044, createdName=锋行天下, createdTime=Wed Dec 23 00:40:19 CST 2020, time=2020-12-23, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1951776, encodeId=3d411951e763f, content=<a href='/topic/show?id=6a53e17507d' target=_blank style='color:#2F92EE;'>#白细胞计数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71750, encryptionId=6a53e17507d, topicName=白细胞计数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8346212, createdName=respect, createdTime=Sun Dec 05 07:32:11 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977984, encodeId=f61e19e7984e5, content=<a href='/topic/show?id=20411e958de' target=_blank style='color:#2F92EE;'>#TVB#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17958, encryptionId=20411e958de, topicName=TVB)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910938, encodeId=699791093830, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/06/19/425bda35e83de63900d3afe3ba2e5cd0.jpg, createdBy=53612384207, createdName=1231cf9dm12暂无昵称, createdTime=Fri Dec 25 18:03:29 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316451, encodeId=f1dc13164515e, content=<a href='/topic/show?id=73f386080a' target=_blank style='color:#2F92EE;'>#HDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8608, encryptionId=73f386080a, topicName=HDL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416523, encodeId=c8e5141652362, content=<a href='/topic/show?id=166b861857' target=_blank style='color:#2F92EE;'>#HDL胆固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8618, encryptionId=166b861857, topicName=HDL胆固醇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ddb3195652, createdName=Eleven12, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578569, encodeId=5e6915e856993, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910242, encodeId=dffc91024226, content=意义是?, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=090d49833, createdName=LaserDermatol, createdTime=Wed Dec 23 00:40:59 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910241, encodeId=eba8910241f2, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160325/IMG56F49530925803400.jpg, createdBy=bfa61632044, createdName=锋行天下, createdTime=Wed Dec 23 00:40:19 CST 2020, time=2020-12-23, status=1, ipAttribution=)]
    2020-12-23 LaserDermatol

    意义是?

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1951776, encodeId=3d411951e763f, content=<a href='/topic/show?id=6a53e17507d' target=_blank style='color:#2F92EE;'>#白细胞计数#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71750, encryptionId=6a53e17507d, topicName=白细胞计数)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8346212, createdName=respect, createdTime=Sun Dec 05 07:32:11 CST 2021, time=2021-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1977984, encodeId=f61e19e7984e5, content=<a href='/topic/show?id=20411e958de' target=_blank style='color:#2F92EE;'>#TVB#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17958, encryptionId=20411e958de, topicName=TVB)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910938, encodeId=699791093830, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/06/19/425bda35e83de63900d3afe3ba2e5cd0.jpg, createdBy=53612384207, createdName=1231cf9dm12暂无昵称, createdTime=Fri Dec 25 18:03:29 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316451, encodeId=f1dc13164515e, content=<a href='/topic/show?id=73f386080a' target=_blank style='color:#2F92EE;'>#HDL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8608, encryptionId=73f386080a, topicName=HDL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416523, encodeId=c8e5141652362, content=<a href='/topic/show?id=166b861857' target=_blank style='color:#2F92EE;'>#HDL胆固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8618, encryptionId=166b861857, topicName=HDL胆固醇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6ddb3195652, createdName=Eleven12, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1578569, encodeId=5e6915e856993, content=<a href='/topic/show?id=fd724282021' target=_blank style='color:#2F92EE;'>#外周血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42820, encryptionId=fd724282021, topicName=外周血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a31916414168, createdName=ms3994565386320060, createdTime=Wed Dec 23 13:32:11 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910242, encodeId=dffc91024226, content=意义是?, beContent=null, objectType=article, channel=null, level=null, likeNumber=155, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=090d49833, createdName=LaserDermatol, createdTime=Wed Dec 23 00:40:59 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910241, encodeId=eba8910241f2, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160325/IMG56F49530925803400.jpg, createdBy=bfa61632044, createdName=锋行天下, createdTime=Wed Dec 23 00:40:19 CST 2020, time=2020-12-23, status=1, ipAttribution=)]
    2020-12-23 锋行天下

    学习了

    0

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