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JAMA Intern Med:粪便免疫化学试验用于结肠癌风险评估

2017-06-21 zhangfan MedSci原创

粪便免疫化学试验对于平均风险以上结肠癌患者的患癌风险检测表现出较高的准确性,但对于其他类型的晚期肿瘤的检测能力适中

近日研究人员考察了粪便免疫化学试验(FIT)对患者直肠癌(CRC)风险筛查的作用。

研究人员在无症状的高风险患者中考察FIT对结肠癌或晚期肿瘤(AN)诊断的准确性。独立的研究人员利用2种工具独立提取数据和评估研究质量进而对诊断准确性研究进行质量评估,并通过等级评定证据质量。利用分层模型综合现有证据。主要目的是评估FIT用于CRC以及AN的准确性。

研究综合分析了12个临床试验,总计6204患者,其中有7项研究被认为是高风险或不明确的偏倚风险。FIT对于CRC检测的平均敏感性为93% (95% CI,53%-99%), 平均特异性为91% (95% CI,89%-92%),产生正似然比 (LR+) 为10.30 (CI 7.7-13.9),负似然比 (LR-)为 0.08 (95% CI,0.01-0.75) 。FIT对于AN检测的平均敏感性为48% (95% CI,39%-57%), 平均特异性为93% (95% CI,91%-94%),产生正似然比 (LR+) 为6.55 (95% CI,5.0-8.5),负似然比 (LR-)为 0.57 (95% CI,0.48-0.67)。亚组分析表明FIT检测限在15- 25μg/g粪便样本为CRC诊断提供最佳灵敏度(93%)和特异性(94%)。

研究表明粪便免疫化学试验对于平均风险以上结肠癌患者的患癌风险检测表现出较高的准确性,但对于其他类型的晚期肿瘤的检测能力适中。

原始出处:


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    2017-11-28 sjq027
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    2017-08-31 情途末路

    学习了.获益匪浅!感谢分享

    0

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    2017-06-23 Homburg
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    2017-06-23 hfuym10906

    学习了

    0

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    2017-06-21 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1772878, encodeId=a9ab1e728782d, content=<a href='/topic/show?id=d7e1e6312cd' target=_blank style='color:#2F92EE;'>#粪便免疫化学试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76312, encryptionId=d7e1e6312cd, topicName=粪便免疫化学试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=87e738436293, createdName=makuansheng, createdTime=Thu Jul 13 06:28:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061634, encodeId=9040206163407, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Nov 28 06:28:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238990, encodeId=fa2923899007, content=学习了.获益匪浅!感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/17/0ed05bbc4eb124766d2a39104932ec4e.jpg, createdBy=5afd2091871, createdName=情途末路, createdTime=Thu Aug 31 13:02:32 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466802, encodeId=a551146680243, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Fri Jun 23 07:28:00 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607694, encodeId=8e45160e694ae, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Jun 23 07:28:00 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214171, encodeId=b8492141e108, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Fri Jun 23 06:39:00 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213554, encodeId=c3432135544b, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Wed Jun 21 17:08:24 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213547, encodeId=292721354e05, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Jun 21 16:53:18 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213536, encodeId=805c2135364b, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Wed Jun 21 16:30:49 CST 2017, time=2017-06-21, status=1, ipAttribution=)]
    2017-06-21 131****1460

    学习了受益匪浅。

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1772878, encodeId=a9ab1e728782d, content=<a href='/topic/show?id=d7e1e6312cd' target=_blank style='color:#2F92EE;'>#粪便免疫化学试验#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76312, encryptionId=d7e1e6312cd, topicName=粪便免疫化学试验)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=87e738436293, createdName=makuansheng, createdTime=Thu Jul 13 06:28:00 CST 2017, time=2017-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061634, encodeId=9040206163407, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Tue Nov 28 06:28:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238990, encodeId=fa2923899007, content=学习了.获益匪浅!感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/17/0ed05bbc4eb124766d2a39104932ec4e.jpg, createdBy=5afd2091871, createdName=情途末路, createdTime=Thu Aug 31 13:02:32 CST 2017, time=2017-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466802, encodeId=a551146680243, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Fri Jun 23 07:28:00 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1607694, encodeId=8e45160e694ae, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri Jun 23 07:28:00 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=214171, encodeId=b8492141e108, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Fri Jun 23 06:39:00 CST 2017, time=2017-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213554, encodeId=c3432135544b, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Wed Jun 21 17:08:24 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213547, encodeId=292721354e05, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Jun 21 16:53:18 CST 2017, time=2017-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213536, encodeId=805c2135364b, content=学习了很好的内容, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJiaCBO9f33YY0a9cL4rhSH23PNEOVia2szWTbUl6IgFnukCuC2ptOD5mAC0Ax8qGt2pjwudkREHlmA/132, createdBy=d39e1630897, createdName=1dd8aa01m06(暂无匿称), createdTime=Wed Jun 21 16:30:49 CST 2017, time=2017-06-21, status=1, ipAttribution=)]
    2017-06-21 1dd8aa01m06(暂无匿称)

    学习了很好的内容

    0

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