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JAHA:来源不明的栓塞性卒中患者颈动脉斑块成分的性别差异

2021-04-28 MedSci原创 MedSci原创

ESUS患者颈动脉斑块成分的性别差异表明,非狭窄性颈动脉斑块在男性和女性卒中发生机制中存在差异。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员评估了来源不明的栓塞性卒中(ESUS)患者非狭窄性颈动脉斑块成分的性别差异。

研究人员确定了符合ESUS标准且经颈部CT血管造影成像检查的前循环缺血性卒中患者或房颤患者。房颤患者作为阴性对照。半自动化斑块定量软件分析了颈动脉分叉部位的斑块成分。

研究人员按性别比较斑块成分(钙、斑块内出血[IPH]和富含脂质的坏死核心)的体积,并通过配对分析对卒中同侧与对侧进行比较。研究人员进行了多元线性回归分析评估了相关性。

研究人员共确定了94例ESUS患者(55%为女性)和95例房颤患者(47%为女性)。ESUS男性颈动脉斑块中钙化斑块(63.9 vs. 19.6 mm3,P<0.001)、IPH(9.4 vs. 3.3 mm3,P=0.008)和IPH/脂质丰富的坏死核心比(0.17 vs. 0.07,P=0.03)比女性体积明显增加。房颤队列卒中后同侧的斑块体积无明显性别差异。ESUS患者队列的多变量分析显示,男性与IPH(β=0.49; 95%CI为0.11-0.87)和钙化(β=0.78; 95%CI为0.33-1.23)相关。ESUS男性的配对斑块分析显示钙化斑块(63.9 vs. 34.1 mm3,P = 0.03)、IPH(9.4 vs. 7.5 mm3,P=0.73)和富含脂质的坏死核心(59.0 vs. 48.4 mm3,P=0.94)体积明显增高。

由此可见,ESUS患者颈动脉斑块成分的性别差异表明,非狭窄性颈动脉斑块在男性和女性卒中发生机制中存在差异。

原始出处:

Jae W. Song.et al.Sex Differences in Carotid Plaque Composition in Patients With Embolic Stroke of Undetermined Source.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.020143

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    2021-04-29 zhaohui6731
  4. [GetPortalCommentsPageByObjectIdResponse(id=1720381, encodeId=0e331e203810f, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Wed Apr 28 19:05:28 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843617, encodeId=bbb7184361e1f, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=416347, createdName=mhzhuang@stu.e, createdTime=Sat Aug 07 01:05:28 CST 2021, time=2021-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268513, encodeId=e6bc12685137a, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Apr 29 15:05:28 CST 2021, time=2021-04-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280792, encodeId=76a61280e9271, content=<a href='/topic/show?id=c6ba1005490e' target=_blank style='color:#2F92EE;'>#颈动脉斑块#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, 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GetPortalCommentsPageByObjectIdResponse(id=961102, encodeId=598c96110275, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/vyAkV8zQqYbLSIGQRrZmSqLvwibFDXpiaOuvIibCUFSwLp2ID4nTOupHSU2ygjh7vUqoibglOLZwQrrF8SdchMVIibg/132, createdBy=02b72465928, createdName=124292adm29暂无昵称, createdTime=Wed Apr 28 06:32:04 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961101, encodeId=e24a96110146, content=颈动脉狭窄导致卒中, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/vyAkV8zQqYbLSIGQRrZmSqLvwibFDXpiaOuvIibCUFSwLp2ID4nTOupHSU2ygjh7vUqoibglOLZwQrrF8SdchMVIibg/132, createdBy=02b72465928, createdName=124292adm29暂无昵称, createdTime=Wed Apr 28 06:31:47 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026835, encodeId=2aca102683544, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Apr 28 03:05:28 CST 2021, time=2021-04-28, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1720381, encodeId=0e331e203810f, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Wed Apr 28 19:05:28 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843617, encodeId=bbb7184361e1f, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/vyAkV8zQqYbLSIGQRrZmSqLvwibFDXpiaOuvIibCUFSwLp2ID4nTOupHSU2ygjh7vUqoibglOLZwQrrF8SdchMVIibg/132, createdBy=02b72465928, createdName=124292adm29暂无昵称, createdTime=Wed Apr 28 06:31:47 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026835, encodeId=2aca102683544, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Apr 28 03:05:28 CST 2021, time=2021-04-28, status=1, ipAttribution=)]
  6. 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GetPortalCommentsPageByObjectIdResponse(id=961102, encodeId=598c96110275, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/vyAkV8zQqYbLSIGQRrZmSqLvwibFDXpiaOuvIibCUFSwLp2ID4nTOupHSU2ygjh7vUqoibglOLZwQrrF8SdchMVIibg/132, createdBy=02b72465928, createdName=124292adm29暂无昵称, createdTime=Wed Apr 28 06:32:04 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961101, encodeId=e24a96110146, content=颈动脉狭窄导致卒中, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/vyAkV8zQqYbLSIGQRrZmSqLvwibFDXpiaOuvIibCUFSwLp2ID4nTOupHSU2ygjh7vUqoibglOLZwQrrF8SdchMVIibg/132, createdBy=02b72465928, createdName=124292adm29暂无昵称, createdTime=Wed Apr 28 06:31:47 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026835, encodeId=2aca102683544, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Apr 28 03:05:28 CST 2021, time=2021-04-28, status=1, ipAttribution=)]
  7. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/vyAkV8zQqYbLSIGQRrZmSqLvwibFDXpiaOuvIibCUFSwLp2ID4nTOupHSU2ygjh7vUqoibglOLZwQrrF8SdchMVIibg/132, createdBy=02b72465928, createdName=124292adm29暂无昵称, createdTime=Wed Apr 28 06:31:47 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026835, encodeId=2aca102683544, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Apr 28 03:05:28 CST 2021, time=2021-04-28, status=1, ipAttribution=)]
    2021-04-28 skywalk3004

    学习了。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1720381, encodeId=0e331e203810f, content=<a href='/topic/show?id=915c3604e6b' target=_blank style='color:#2F92EE;'>#卒中患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36047, encryptionId=915c3604e6b, topicName=卒中患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=940232842333, createdName=wangyang7969, createdTime=Wed Apr 28 19:05:28 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1843617, encodeId=bbb7184361e1f, content=<a href='/topic/show?id=dab8100523bb' target=_blank style='color:#2F92EE;'>#颈动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100523, encryptionId=dab8100523bb, topicName=颈动脉)], attachment=null, authenticateStatus=null, createdAvatar=, 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  9. 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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/vyAkV8zQqYbLSIGQRrZmSqLvwibFDXpiaOuvIibCUFSwLp2ID4nTOupHSU2ygjh7vUqoibglOLZwQrrF8SdchMVIibg/132, createdBy=02b72465928, createdName=124292adm29暂无昵称, createdTime=Wed Apr 28 06:31:47 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026835, encodeId=2aca102683544, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Apr 28 03:05:28 CST 2021, time=2021-04-28, status=1, ipAttribution=)]
    2021-04-28 124292adm29暂无昵称

    颈动脉狭窄导致卒中

    0

  10. 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GetPortalCommentsPageByObjectIdResponse(id=961102, encodeId=598c96110275, content=<a href='/topic/show?id=1c1710265113' target=_blank style='color:#2F92EE;'>#高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102651, encryptionId=1c1710265113, topicName=高血压)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/vyAkV8zQqYbLSIGQRrZmSqLvwibFDXpiaOuvIibCUFSwLp2ID4nTOupHSU2ygjh7vUqoibglOLZwQrrF8SdchMVIibg/132, createdBy=02b72465928, createdName=124292adm29暂无昵称, createdTime=Wed Apr 28 06:32:04 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=961101, encodeId=e24a96110146, content=颈动脉狭窄导致卒中, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/vyAkV8zQqYbLSIGQRrZmSqLvwibFDXpiaOuvIibCUFSwLp2ID4nTOupHSU2ygjh7vUqoibglOLZwQrrF8SdchMVIibg/132, createdBy=02b72465928, createdName=124292adm29暂无昵称, createdTime=Wed Apr 28 06:31:47 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026835, encodeId=2aca102683544, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Wed Apr 28 03:05:28 CST 2021, time=2021-04-28, status=1, ipAttribution=)]
    2021-04-28 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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