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Diabetes Care:每天睡眠时间变化仅超过1小时,代谢异常风险就有可能增加27%!

2019-06-10 佚名 生物通

一项研究将不规则睡眠模式与代谢紊乱联系了起来:不遵守规律的就寝时间和起床时间会使人更容易患上肥胖、高胆固醇、高血压、高血糖和其他代谢紊乱。事实上,上床睡觉时间和睡眠总量每变化1小时,一个人经历代谢异常的风险将增加高达27%。


一项研究将不规则睡眠模式与代谢紊乱联系了起来:不遵守规律的就寝时间和起床时间会使人更容易患上肥胖、高胆固醇高血压、高血糖和其他代谢紊乱。事实上,上床睡觉时间和睡眠总量每变化1小时,一个人经历代谢异常的风险将增加高达27%。

研究由国家心、肺和血液研究所(National Heart, Lung, and Blood Institute,NHLBI)资助。

“许多以前的研究称,睡眠不足与肥胖、糖尿病和其他代谢紊乱高风险之间有联系,”文章作者、波士顿Brigham和妇女医院网络医学部的流行病学家Tianyi Huang说。“但我们对睡眠不规律、睡眠持续时间和日复一日的高变化性的影响知之甚少。我们的研究表明,考虑到一个人的睡眠量和其他生活方式因素,每晚每增加一个小时的睡眠差异(入睡时间或睡眠总量)就会使代谢不良效应成倍增加。”

研究人员调查了2003年参与NHLBI动脉粥样硬化多民族研究(MESA)的45至84岁男性和女性,对参与者进行了中位数为6年的跟踪研究,目的是找出睡眠规律性与代谢异常之间的关系。为了确保对睡眠时间和质量的客观测量,参与者都佩戴了密切跟踪睡眠情况的腕表(可连续监测7天),还记录了睡眠日记,并对有关睡眠习惯和其他生活方式和健康因素的标准调查问卷作出了回应。参与者在2010年至2013年陆续完成了体动记录仪跟踪部分,随后调查研究一直跟踪到2016年至2017年。

NHLBI国家睡眠障碍研究中心主任Michael Twery博士说:“客观指标和大而多样的样本量是这项研究的优势。这项研究不仅着眼于当前的因素,而且也有前瞻性分析,使我们能够评估不规则睡眠模式是否与未来的代谢异常有关。”

研究人员假设关联存在,而调查结果也证明确实如此。就寝时间和睡眠时间差异较大的个体代谢问题的发生率较高,在调整了平均睡眠时间后,这些关联仍然存在。在6.3年的随访中,研究对象出现代谢紊乱的情况也与之相符。

前瞻性结果显示,睡眠时间和就寝时间的变化对代谢功能障碍发展具有可预见性。根据作者的说法,这提供了一些支持不规则睡眠和代谢功能障碍之间因果关系的证据。

睡眠时间变化超过一小时的参与者更有可能是非裔美国人、非白班工作者、吸烟者,并且他们的睡眠持续时间普遍更短。他们也有较高的抑郁症状、总热量摄入和睡眠呼吸暂停指数。

然而,增加睡眠时间或入睡时间波动与多种代谢和随之出现的问题(如低HDL胆固醇、高腰围、血压、总甘油三酯和空腹血糖)密切相关。

“我们的研究结果表明,保持规律的睡眠时间对新陈代谢有好处,”合著者、Brigham和妇女医院睡眠和昼夜节律紊乱部的高级医师Susan Redline医学博士说。“这一信息将丰富当前代谢性疾病的预防策略,主要集中于促进充足的睡眠和其他健康的生活方式。”

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    2019-07-25 zhouqu_8
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    2019-06-10 天地飞扬

    学习了,睡觉了

    0

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