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MJ:分子和免疫学分析间日疟复发

2017-06-21 MedSci MedSci原创

间日疟复发
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由间日疟原虫和卵形疟原虫的休眠体激活所引起的复发给疟疾的控制带来了严重的障碍。 伯氨喹作为一种单一的许可药物，可用于消除肝脏中的休眠体。迄今为止，关于间日疟原虫感染的研究仍很少。

由间日疟原虫和卵形疟原虫的休眠体激活所引起的复发给疟疾的控制带来了严重的障碍。 伯氨喹作为一种单一的许可药物，可用于消除肝脏中的休眠体。迄今为止，关于间日疟原虫感染的研究仍很少。

本研究基于两个基因（Pvmsp1F3和Pvcsp）和四个微卫星标记（MS3.27，MS3.502，MS6和MS8）的多态性区域，对12对经过伯氨喹治疗后复发的间日疟患者的样品进行测定。研究显示8个间日疟原虫群体在入院的复发样品中是同源的，在剩余的四个患者中是异源的。患者的CYP2D6基因型并没有表明伯氨喹的代谢不良。与同源性复发事件中的IgG3反应相比，原虫血症往往在异源群体中较高。对于所有样品中的十二个促炎细胞因子水平进行测定，与入院和复发事件中的同源相比，只有IL-6和IL-10在异源性患者中较高。

从有限数量确诊的复发患者中所获得数据反映了先前所观察到泰国间日疟原虫复发感染中存在数目较大的异源原虫群体。患者接受初次治疗的失败是由药物代谢不良所致的可能性较小，而很可能是由于在泰国存在对8-氨基喹啉敏感性差的间日疟原虫群体。

原始出处：

Sarunya ManeerattanasakPanita GosiSrivicha Krudsood,et.al. Molecular and immunological analyses of confirmed Plasmodium vivax relapse episodes.

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    2017-11-23 xiaoyeshuang

    #免疫学#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1889410, encodeId=d0271889410f0, content=<a href='/topic/show?id=f9fa290030a' target=_blank style='color:#2F92EE;'>#免疫学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29003, encryptionId=f9fa290030a, topicName=免疫学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Nov 23 04:59:00 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988127, encodeId=9290198812ecb, content=<a href='/topic/show?id=1b9f9e2582d' target=_blank style='color:#2F92EE;'>#间日疟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97258, encryptionId=1b9f9e2582d, topicName=间日疟)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Mar 12 04:59:00 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213739, encodeId=ce87213e3985, content=学习了，很好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Thu Jun 22 07:09:54 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213668, encodeId=d22821366885, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Thu Jun 22 00:37:39 CST 2017, time=2017-06-22, status=1, ipAttribution=)]
    2018-03-12 仁心济世

    #间日疟#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1889410, encodeId=d0271889410f0, content=<a href='/topic/show?id=f9fa290030a' target=_blank style='color:#2F92EE;'>#免疫学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29003, encryptionId=f9fa290030a, topicName=免疫学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Thu Nov 23 04:59:00 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988127, encodeId=9290198812ecb, content=<a href='/topic/show?id=1b9f9e2582d' target=_blank style='color:#2F92EE;'>#间日疟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97258, encryptionId=1b9f9e2582d, topicName=间日疟)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Mar 12 04:59:00 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213739, encodeId=ce87213e3985, content=学习了，很好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Thu Jun 22 07:09:54 CST 2017, time=2017-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=213668, encodeId=d22821366885, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Thu Jun 22 00:37:39 CST 2017, time=2017-06-22, status=1, ipAttribution=)]
    2017-06-22 stupidox

    学习了，很好。

    0

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    2017-06-22 189****7206

    学习了受益匪浅

    0

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Malar J：孕妇感染间日疟原虫会怎样？

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