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ACNP:为什么孤独症多见于男性?——大脑发育的性别差异研究

2015-12-13 Mechront 译 MedSci原创

有趣的是,一些早发型神经发育相关疾病如孤独症谱系障碍(ASD)常常多见于男性。为什么会存在性别差异?目前对大脑发育的性别差异认识不足,导致不能很好的理解发病率的性别差异。不过美国神经精神药理学年会上报道的一项新研究提到,女婴比同时期男友,大脑颞顶部链接区(TP)灰质体积更大。TP位于靠近耳朵的颞骨下,整合对别人面孔和声音等信息的处理,而ASD患者该种能力受损。TP区域的性别差异可能是男性更容发生A

有趣的是,一些早发型神经发育相关疾病如孤独症谱系障碍(ASD)常常多见于男性。为什么会存在性别差异?

目前对大脑发育的性别差异认识不足,导致不能很好的理解发病率的性别差异。不过美国神经精神药理学年会上报道的一项新研究提到,女婴比同时期男婴,大脑颞顶部链接区(TP)灰质体积更大。

TP位于靠近耳朵的颞骨下,整合对别人面孔和声音等信息的处理,而ASD患者该种能力受损。TP区域的性别差异可能是男性更容发生ASD的原因之一,也为研究提供了线索。

北卡罗来纳大学教堂山分校的Rebecca Knickmeyer及其团队对超过800名正常新生儿进行研究,随访至2岁,试验期间通过唾液检测性激素水平以及大脑影像学检查,发现了大脑发育的性别差异。

不仅如此该团队还发现,2岁时大脑髓鞘形成男孩多于女孩。神经周围包裹绝缘髓鞘即是髓鞘形成,可以让信息传递更快。

此外Knickmeyer还研究了只在女性中发生的疾病——特纳综合征患者的大脑发育。该疾病因X染色体部分或完全丢失导致,而疾病患者顶叶下部大脑体积明显下降。该现象表明,至少对于女性,性染色体会影响顶叶下部的发育。

原始出处:

Sex Differences in the Infant Brain: Mechanistic Considerations and Relevance to Neurodevelopmental Disorders.neuropsychopharmacology.2015

Sex differences in brain may underlie neurodevelopmental disorders more common in males
.MNT.2015

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    2016-03-03 勇敢的医生

    这篇文章值得学习一下

    0

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    2016-01-28 1de3b290m83(暂无匿称)

    男人不容易

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1715215, encodeId=61331e1521564, content=<a href='/topic/show?id=1f5749338a' target=_blank style='color:#2F92EE;'>#CNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4933, encryptionId=1f5749338a, topicName=CNP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bb0631916556, createdName=minhuang75_72521594, createdTime=Sat Dec 26 15:49:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950517, encodeId=3cad195051e95, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Fri Feb 12 18:49:00 CST 2016, time=2016-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66940, encodeId=cbd966940de, content=这篇文章值得学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51621695073, createdName=勇敢的医生, createdTime=Thu Mar 03 00:20:00 CST 2016, time=2016-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61682, encodeId=577161682cc, content=男人不容易, beContent=null, objectType=article, channel=null, level=null, likeNumber=232, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Thu Jan 28 02:22:00 CST 2016, time=2016-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48452, encodeId=c08448452b3, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48453, encodeId=1b6e48453c0, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=224, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48454, encodeId=72174845470, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347074, encodeId=0d0f134e074bf, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Dec 15 09:49:00 CST 2015, time=2015-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399521, encodeId=9c2c139952151, content=<a href='/topic/show?id=abae4388359' target=_blank style='color:#2F92EE;'>#大脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43883, encryptionId=abae4388359, topicName=大脑发育)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/ED2CC9E7989F19A8FE1EC8C4B58CDA69/100, createdBy=cdee2217473, createdName=gj0732, createdTime=Tue Dec 15 09:49:00 CST 2015, time=2015-12-15, status=1, ipAttribution=)]
    2015-12-26 hixiaoluo

    好文章,值得看。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1715215, encodeId=61331e1521564, content=<a href='/topic/show?id=1f5749338a' target=_blank style='color:#2F92EE;'>#CNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4933, encryptionId=1f5749338a, topicName=CNP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bb0631916556, createdName=minhuang75_72521594, createdTime=Sat Dec 26 15:49:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950517, encodeId=3cad195051e95, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Fri Feb 12 18:49:00 CST 2016, time=2016-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66940, encodeId=cbd966940de, content=这篇文章值得学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51621695073, createdName=勇敢的医生, createdTime=Thu Mar 03 00:20:00 CST 2016, time=2016-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61682, encodeId=577161682cc, content=男人不容易, beContent=null, objectType=article, channel=null, level=null, likeNumber=232, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Thu Jan 28 02:22:00 CST 2016, time=2016-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48452, encodeId=c08448452b3, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48453, encodeId=1b6e48453c0, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=224, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48454, encodeId=72174845470, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347074, encodeId=0d0f134e074bf, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Dec 15 09:49:00 CST 2015, time=2015-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399521, encodeId=9c2c139952151, content=<a href='/topic/show?id=abae4388359' target=_blank style='color:#2F92EE;'>#大脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43883, encryptionId=abae4388359, topicName=大脑发育)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/ED2CC9E7989F19A8FE1EC8C4B58CDA69/100, createdBy=cdee2217473, createdName=gj0732, createdTime=Tue Dec 15 09:49:00 CST 2015, time=2015-12-15, status=1, ipAttribution=)]
    2015-12-26 hixiaoluo

    好文章,值得看。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1715215, encodeId=61331e1521564, content=<a href='/topic/show?id=1f5749338a' target=_blank style='color:#2F92EE;'>#CNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4933, encryptionId=1f5749338a, topicName=CNP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bb0631916556, createdName=minhuang75_72521594, createdTime=Sat Dec 26 15:49:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950517, encodeId=3cad195051e95, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Fri Feb 12 18:49:00 CST 2016, time=2016-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66940, encodeId=cbd966940de, content=这篇文章值得学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51621695073, createdName=勇敢的医生, createdTime=Thu Mar 03 00:20:00 CST 2016, time=2016-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61682, encodeId=577161682cc, content=男人不容易, beContent=null, objectType=article, channel=null, level=null, likeNumber=232, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Thu Jan 28 02:22:00 CST 2016, time=2016-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48452, encodeId=c08448452b3, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48453, encodeId=1b6e48453c0, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=224, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48454, encodeId=72174845470, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347074, encodeId=0d0f134e074bf, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Dec 15 09:49:00 CST 2015, time=2015-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399521, encodeId=9c2c139952151, content=<a href='/topic/show?id=abae4388359' target=_blank style='color:#2F92EE;'>#大脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43883, encryptionId=abae4388359, topicName=大脑发育)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/ED2CC9E7989F19A8FE1EC8C4B58CDA69/100, createdBy=cdee2217473, createdName=gj0732, createdTime=Tue Dec 15 09:49:00 CST 2015, time=2015-12-15, status=1, ipAttribution=)]
    2015-12-26 hixiaoluo

    好文章,值得看。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1715215, encodeId=61331e1521564, content=<a href='/topic/show?id=1f5749338a' target=_blank style='color:#2F92EE;'>#CNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4933, encryptionId=1f5749338a, topicName=CNP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bb0631916556, createdName=minhuang75_72521594, createdTime=Sat Dec 26 15:49:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950517, encodeId=3cad195051e95, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Fri Feb 12 18:49:00 CST 2016, time=2016-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=66940, encodeId=cbd966940de, content=这篇文章值得学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=190, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51621695073, createdName=勇敢的医生, createdTime=Thu Mar 03 00:20:00 CST 2016, time=2016-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=61682, encodeId=577161682cc, content=男人不容易, beContent=null, objectType=article, channel=null, level=null, likeNumber=232, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Thu Jan 28 02:22:00 CST 2016, time=2016-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48452, encodeId=c08448452b3, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=179, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48453, encodeId=1b6e48453c0, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=224, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48454, encodeId=72174845470, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 17:16:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347074, encodeId=0d0f134e074bf, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Tue Dec 15 09:49:00 CST 2015, time=2015-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399521, encodeId=9c2c139952151, content=<a href='/topic/show?id=abae4388359' target=_blank style='color:#2F92EE;'>#大脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43883, encryptionId=abae4388359, topicName=大脑发育)], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/ED2CC9E7989F19A8FE1EC8C4B58CDA69/100, createdBy=cdee2217473, createdName=gj0732, createdTime=Tue Dec 15 09:49:00 CST 2015, time=2015-12-15, status=1, ipAttribution=)]
    2015-12-15 neurowu
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