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Stroke:内脏脂肪组织对急性缺血性卒中后临床结局的影响

2019-01-07 xing.T MedSci原创

由此可见,该研究的结果表明低内脏腹部脂肪比例与静脉溶栓治疗的急性缺血性卒中患者有利和优异结局相关。肥胖患者更好的临床结局也与较低比例的VAT有关。

近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,该研究的目的是调查脂肪组织成像确定的肥胖与接受静脉溶栓治疗的急性缺血性卒中患者结局之间的关系。

这项前瞻性队列研究共纳入127名接受静脉溶栓治疗的急性缺血性卒中患者,他们入院时进行了腹部计算机断层扫描。根据患者的内脏脂肪组织(VAT)比例三分位数对患者进行分组。在症状出现后3个月使用改良的Rankin量表测量主要结局。有利和优异的结局被定义为改良Rankin量表分数分别为0到2和0到1。

随着VAT比例的三分位数增加,表现出良好或优异结局的患者数量减少。在对混杂因素进行调整后的最终多变量分析中,与最低三分位数相比,VAT比例最高三分位数的患者显示出有利和优异结局的概率降低(分别有比值比=0.18; 95%CI为0.05-0.60; P=0.005和比值比=0.13; 95%CI为0.02-0.64; P=0.012)。与非肥胖患者相比,肥胖患者(体重指数≥25)也表现出优异的结局(比值比=4.88; 95%CI为1.47-7.85; P=0.011)。在肥胖患者中,具有优异结局的患者VAT比例显著低于没有优异结局的患者(38.2% vs. 46.1%,P=0.006)。

由此可见,该研究的结果表明低内脏腹部脂肪比例与静脉溶栓治疗的急性缺血性卒中患者有利和优异结局相关。肥胖患者更好的临床结局也与较低比例的VAT有关。

原始出处:

Ja-Hae Kim.et al.Impact of Visceral Adipose Tissue on Clinical Outcomes After Acute Ischemic Stroke.Stroke.2018.https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.023421

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    2019-01-12 一个字-牛

    学习了谢谢分享

    0

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    2019-01-07 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

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