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CLIN CANCER RES：伊匹单抗联合来那度胺治疗干细胞移植后淋巴系统恶性肿瘤

2018-03-04 MedSci MedSci原创

淋巴系统恶性肿瘤干细胞移植伊匹单抗来那度胺
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造血干细胞移植后阻止或治疗淋巴系统恶性肿瘤复发需要完整的策略。CLIN CANCER RES近期发表了一篇文章，研究来那度胺是否可以增强CTLA-4抑制剂伊匹单抗的抗肿瘤效果

造血干细胞移植后阻止或治疗淋巴系统恶性肿瘤复发需要完整的策略。CLIN CANCER RES近期发表了一篇文章，研究来那度胺是否可以增强CTLA-4抑制剂伊匹单抗的抗肿瘤效果。

研究纳入的为异体造血干细胞移植后复发的患者和自体造血干细胞移植后高风险的患者，进行Ⅱ期试验评估伊匹单抗联合来那度胺的安全性和抗肿瘤活性。患者每天口服10mg来那度胺21天后静脉输入伊匹单抗3mg/kg体重。四周后重复进行治疗，共4个疗程。最终纳入17例患者（10例异体移植和7例自体移植）。在异体移植组和自体移植组分别出现1例免疫相关毒性，为无症状的甲状腺功能减退和皮炎。1例接受异体移植的患者在进行来那度胺治疗时出现移植物抗宿主反应（GVHD），未进行进一步治疗。其余患者完成治疗，并未出现GVHD。异体移植组10例患者中4例出现完全反应，3例出现部分反应。自体移植组7例患者中6例持续病情缓解。两组免疫反应相似，包括ICOS+CD4+FoxP3-T细胞数量增加2-3倍。

文章最后认为，伊匹单抗联合来那度胺在造血干细胞移植后耐受性良好。异体移植组和自体移植组之间不良反应无显着差别。

原始出处：
Issa F.Khouri,Irina Fernandez Curbelo,et al.Ipilimumab plus Lenalidomide after Allogeneic and Autologous Stem Cell Transplantation for Patients with Lymphoid Malignancies.CLIN CANCER RES.March 2018 doi:10.1158/1078-0432.CCR-17-2777

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    2018-06-01 limedical1982

    #细胞移植#

    0

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    2018-05-07 童小孩

    学习

    0

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    2018-05-06 童小孩

    学习

    0

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    2018-04-06 童小孩

    学习

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1658853, encodeId=894816588533e, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Fri Jun 01 18:00:00 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312663, encodeId=e96e3126636f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Mon May 07 00:02:16 CST 2018, time=2018-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312642, encodeId=31da3126424a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Sun May 06 23:01:07 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303372, encodeId=91333033e2db, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Fri Apr 06 21:13:46 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512331, encodeId=79f2151233195, content=<a href='/topic/show?id=c73d6598434' target=_blank style='color:#2F92EE;'>#淋巴系统#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65984, encryptionId=c73d6598434, topicName=淋巴系统)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f36a10457757, createdName=ms7514935887898259, createdTime=Tue Mar 06 10:00:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293282, encodeId=7a03293282e9, content=学习了不少事情!, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Mar 05 18:47:29 CST 2018, time=2018-03-05, status=1, ipAttribution=)]
    2018-03-06 ms7514935887898259

    #淋巴系统#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1658853, encodeId=894816588533e, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Fri Jun 01 18:00:00 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312663, encodeId=e96e3126636f, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Mon May 07 00:02:16 CST 2018, time=2018-05-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=312642, encodeId=31da3126424a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Sun May 06 23:01:07 CST 2018, time=2018-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=303372, encodeId=91333033e2db, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K3j7ibEWPiarwpqibEYqqX9yVibV5uebib0O7hQSOPmqGrb5FfyDbLsLawnz7ShAb5ibtiayWgI5ClMTh5v/0, createdBy=a47c1614293, createdName=童小孩, createdTime=Fri Apr 06 21:13:46 CST 2018, time=2018-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512331, encodeId=79f2151233195, content=<a href='/topic/show?id=c73d6598434' target=_blank style='color:#2F92EE;'>#淋巴系统#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65984, encryptionId=c73d6598434, topicName=淋巴系统)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f36a10457757, createdName=ms7514935887898259, createdTime=Tue Mar 06 10:00:00 CST 2018, time=2018-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=293282, encodeId=7a03293282e9, content=学习了不少事情!, beContent=null, objectType=article, channel=null, level=null, likeNumber=148, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Mar 05 18:47:29 CST 2018, time=2018-03-05, status=1, ipAttribution=)]
    2018-03-05 虈亣靌

    学习了不少事情!

    0

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