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Lancet子刊:西安交大:中老年人肌肉减少或导致心血管疾病风险激增!

2022-01-20 MedSci原创 MedSci原创

肌少症可能与中国中老年人的高心血管疾病风险有关。

肌肉减少症是一种严重的老年综合症,表现为骨骼肌肉质量下降,加上肌肉力量低下,及/或体能低下,是老龄化社会面临的公共卫生问题。在过去十年,多项研究报告指出,在亚洲地区的老年人中,"肌肉减少症 "的发病率由6.8%至25.7%不等。

年龄的增长是与心血管疾病(CVD)发展相关的最强风险因素,是老年患者死亡的主要原因之一。最近,越来越多的研究探讨了肌少症与CVD之间的关系,如冠心病、心房颤动、心力衰竭和中风。

目前对中国人群中老年人肌少症与CVD之间的关系知之甚少。为此,来自西安交大附属医院的专家利用中国健康与退休纵向研究(CHARLS)中具有全国代表性的数据,进行了横断面和纵向分析,以研究中国中老年人群中肌肉疏松症状态与心血管疾病之间的关系。结果发表在《柳叶刀》子刊EclinicalMedicine杂志上。

该样本包括15137名年龄在45岁以上的CHARLS 2015的参与者。肌少症状态是根据2019年亚洲肌少症工作组(AWGS 2019)的标准来定义的。CVD为存在医生诊断的心脏病和/或中风。从CHARLS 2015中共招募了11863名无CVD的参与者,并在2018年进行了随访。进行了Cox比例危害回归模型,研究了肌少症对心血管的影响。

在总体人群中,无肌少症、可能的肌少症和肌少症患者的CVD患病率分别为12.6%(1905/15137)、10.0%(1026/10280)、18.1%(668/3685)、18.0%(211/1172)。在总人群中,可能的肌少症[OR(95%CI):1.29(1.13-1.48)]和肌肉疏松症[1.72(1.40-2.10)]分别与CVD风险增加29%和72%有关。

2015-2018年,基线肌少症状态与新发生CVD的纵向关联。

在3.6年的随访中,确定了1273例(10.7%)发生CVD的病例。在纵向分析中,被诊断为可能患有肌少症的人(HR=1.22,95% CI:1.05-1.43)和肌少参与者(HR:1.33,95% CI:1.04-1.71)比没有肌少症的同龄人新发CVD的风险增加22%与33%。

综上,使用2019年AWGS标准评估的"肌少症 "可能与中国中老年人的高心血管疾病风险有关。

 

参考文献:

Association between sarcopenia and cardiovascular disease among middle-aged and older adults: Findings from the China health and retirement longitudinal study. DOI:https://doi.org/10.1016/j.eclinm.2021.101264

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    2022-12-21 howi
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近年来,PCNSL的发病率正在增加,据报道,PCNSL的年龄调整后的发病率为0.16/10万,在65岁以上的老年患者中发病率最高。

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在2型糖尿病患者中,肌肉减少症增加了患心血管疾病的风险,这可能比没有肌肉减少症的人发生得更早。因此,2型糖尿病患者肌肉减少症的筛查和预防可能有助于预防心血管疾病的并发症。

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