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IDF 2012:Hp感染者Th17细胞增加与消化性溃疡有关

2012-07-12 吴莹莹 医学论坛网

英国诺丁汉大学E Staples、R J M Ingram、K Hussain等人在2012英国消化疾病联盟大会(DDF)上做了幽门螺旋杆菌感染患者Th17细胞数增加可能与消化性溃疡有关的口头报告。幽门螺杆菌(Hp)感染的病人胃黏膜中辅助T细胞17和Tc17细胞数量增加,且IL17,RORC2和IFNG的表达增加。其中IL17表达的增加比IFNG表达明显更高,但IL17的来源还没有得到充分证实。在

英国诺丁汉大学E Staples、R J M Ingram、K Hussain等人在2012英国消化疾病联盟大会(DDF)上做了幽门螺旋杆菌感染患者Th17细胞数增加可能与消化性溃疡有关的口头报告。幽门螺杆菌(Hp)感染的病人胃黏膜中辅助T细胞17和Tc17细胞数量增加,且IL17,RORC2和IFNG的表达增加。其中IL17表达的增加比IFNG表达明显更高,但IL17的来源还没有得到充分证实。在消化性溃疡病人的胃黏膜RORC2表达有增加的趋势。研究表明,Th17细胞的免疫应答反应可能会影响病人Hp幽门螺杆菌感染的临床转归。

幽门螺杆菌持续地奴役了一半的世界人口。大部分无症状,但10%至15%将发展成消化性溃疡(PUD)或胃癌。此疾病与干扰素γ-辅助T细胞 1(Th1细胞)反应有关,可能也涉及到Th17,它可产生促炎症介质IL-17并表达转录因子RORC2。鼠类Th17(参与的应答)反应对Hp的影响已明确,而人类Th17反应的作用仍不是很清楚。

该研究评估Th17细胞在Hp阳性患者中的重要性。研究人员量化了人胃粘膜的Th17细胞,且比较了Th17细胞中的IL17, RORC2 和IFNG转录情况,并研究了它们与消化性溃疡的相关性。

经常规上消化道内视镜胃活检标本经知情同意和伦理批准后,由诺丁汉皇后医疗中心的患者捐赠。

病人特点:Hp相关消化性溃疡17例,Hp相关性胃炎28例,未感染(Hp阴性对照)17例。通过实时荧光定量PCR检测了所有病人的活组织切片胃窦部IL17和RORC2 mRNA水平和26例幽门螺杆菌阳性,9例幽门螺杆菌阴性活检组织IFNG转录水平,并与14例未感染Hp者的活检标本比较。使用流式细胞仪分析了12例Hp阳性和11例Hp阴性病人活检组织中分泌IL-17 CD4阳性和CD8阳性T细胞的频率。

统计分析:采用Mann-Whitne检验比较Hp阳性和Hp阴性组、有或无消化性溃疡病人之间的差异。采用Wilcoxon符号秩检验比较配对活检标本mRNA表达水平的。使用Spearman秩相关分析比较组之间的关系。

在Hp阳性患者活检标本中,产生IL-17 CD4阳性的辅助T细胞17和产生IL-17CD8阳性(细胞毒性T细胞17)细胞细胞频率升高。荧光实时定量PCR检测得Hp感染患者粘膜的IL17和IFNG表达上升,并于首次检测时也发现RORC2表达相对增高。IL17和IFNG的表达有相关趋势,在细胞中IL17表达比IFNG高3.1倍。Hp阳性消化性溃疡患者组织中的相关RORC2基因的表达比仅有胃炎患者组织高35%,但无统计学显著性。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=5765, encodeId=e9b35e65cc, content=好可怕啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10b582569, createdName=Clara7750, createdTime=Sun Jun 02 15:02:00 CST 2013, time=2013-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=5766, encodeId=4caf5e661f, content=一定要注意防, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10b582569, createdName=Clara7750, createdTime=Sun Jun 02 15:02:00 CST 2013, time=2013-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=5767, encodeId=e6075e6789, content=积分我来了, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10b582569, createdName=Clara7750, createdTime=Sun Jun 02 15:02:00 CST 2013, time=2013-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1675462, encodeId=b4a916e546249, content=<a href='/topic/show?id=8f1d941219' target=_blank style='color:#2F92EE;'>#IDF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9412, encryptionId=8f1d941219, topicName=IDF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca2627235272, createdName=hxzhang, createdTime=Fri Jan 25 22:12:00 CST 2013, time=2013-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4661, encodeId=482546610f, content=幽门螺杆菌感染是胃炎、胃溃疡发病原因。, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=faa445010, createdName=yangguangrun, createdTime=Sun Aug 26 18:08:00 CST 2012, time=2012-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369738, encodeId=abb11369e383c, content=<a href='/topic/show?id=312e65e4420' target=_blank style='color:#2F92EE;'>#消化性溃疡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65744, encryptionId=312e65e4420, topicName=消化性溃疡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ca4300, createdName=wodejia-dayu, createdTime=Sat Jul 14 06:12:00 CST 2012, time=2012-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413541, encodeId=605f141354144, content=<a href='/topic/show?id=9cd21e364df' target=_blank style='color:#2F92EE;'>#Th17#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17364, encryptionId=9cd21e364df, topicName=Th17)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Jul 14 06:12:00 CST 2012, time=2012-07-14, status=1, ipAttribution=)]
    2013-06-02 Clara7750

    好可怕啊

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=5765, encodeId=e9b35e65cc, content=好可怕啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10b582569, createdName=Clara7750, createdTime=Sun Jun 02 15:02:00 CST 2013, time=2013-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=5766, encodeId=4caf5e661f, content=一定要注意防, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10b582569, createdName=Clara7750, createdTime=Sun Jun 02 15:02:00 CST 2013, time=2013-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=5767, encodeId=e6075e6789, content=积分我来了, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10b582569, createdName=Clara7750, createdTime=Sun Jun 02 15:02:00 CST 2013, time=2013-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1675462, encodeId=b4a916e546249, content=<a href='/topic/show?id=8f1d941219' target=_blank style='color:#2F92EE;'>#IDF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9412, encryptionId=8f1d941219, topicName=IDF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca2627235272, createdName=hxzhang, createdTime=Fri Jan 25 22:12:00 CST 2013, time=2013-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4661, encodeId=482546610f, content=幽门螺杆菌感染是胃炎、胃溃疡发病原因。, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=faa445010, createdName=yangguangrun, createdTime=Sun Aug 26 18:08:00 CST 2012, time=2012-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369738, encodeId=abb11369e383c, content=<a href='/topic/show?id=312e65e4420' target=_blank style='color:#2F92EE;'>#消化性溃疡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65744, encryptionId=312e65e4420, topicName=消化性溃疡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ca4300, createdName=wodejia-dayu, createdTime=Sat Jul 14 06:12:00 CST 2012, time=2012-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413541, encodeId=605f141354144, content=<a href='/topic/show?id=9cd21e364df' target=_blank style='color:#2F92EE;'>#Th17#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17364, encryptionId=9cd21e364df, topicName=Th17)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Jul 14 06:12:00 CST 2012, time=2012-07-14, status=1, ipAttribution=)]
    2013-06-02 Clara7750

    一定要注意防

    0

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    2013-06-02 Clara7750

    积分我来了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=5765, encodeId=e9b35e65cc, content=好可怕啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10b582569, createdName=Clara7750, createdTime=Sun Jun 02 15:02:00 CST 2013, time=2013-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=5766, encodeId=4caf5e661f, content=一定要注意防, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10b582569, createdName=Clara7750, createdTime=Sun Jun 02 15:02:00 CST 2013, time=2013-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=5767, encodeId=e6075e6789, content=积分我来了, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10b582569, createdName=Clara7750, createdTime=Sun Jun 02 15:02:00 CST 2013, time=2013-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1675462, encodeId=b4a916e546249, content=<a href='/topic/show?id=8f1d941219' target=_blank style='color:#2F92EE;'>#IDF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9412, encryptionId=8f1d941219, topicName=IDF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ca2627235272, createdName=hxzhang, createdTime=Fri Jan 25 22:12:00 CST 2013, time=2013-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=4661, encodeId=482546610f, content=幽门螺杆菌感染是胃炎、胃溃疡发病原因。, beContent=null, objectType=article, channel=null, level=null, likeNumber=127, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=faa445010, createdName=yangguangrun, createdTime=Sun Aug 26 18:08:00 CST 2012, time=2012-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1369738, encodeId=abb11369e383c, content=<a href='/topic/show?id=312e65e4420' target=_blank style='color:#2F92EE;'>#消化性溃疡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65744, encryptionId=312e65e4420, topicName=消化性溃疡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7ca4300, createdName=wodejia-dayu, createdTime=Sat Jul 14 06:12:00 CST 2012, time=2012-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1413541, encodeId=605f141354144, content=<a href='/topic/show?id=9cd21e364df' target=_blank style='color:#2F92EE;'>#Th17#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17364, encryptionId=9cd21e364df, topicName=Th17)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Jul 14 06:12:00 CST 2012, time=2012-07-14, status=1, ipAttribution=)]
    2013-01-25 hxzhang
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    2012-08-26 yangguangrun

    幽门螺杆菌感染是胃炎、胃溃疡发病原因。

    0

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    2012-07-14 zhaojie88

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