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Am J Gastroenterol:胃十二指肠功能不全患者的胃运动功能障碍研究

2017-09-16 zhangfan MedSci原创

研究发现功能性胃十二指肠疾病患者存在一个或多个胃运动功能障碍和呼吸窦性心律降低。对于胃运动功能异常的患者,呕吐表明患者可能存在胃排空延缓,呼吸窦性心律降低预示患者可能存在胃容受性降低

消化不良的病理生理因素十分复杂。近日研究人员在一项大型功能性胃肠症状队列研究中评估了胃排空(GE)、胃容受性(GA)和呼吸窦性心律 (RSA, 可反映迷走神经功能障碍)之间的关系。

研究人员对1287名受试者的人口统计学、临床特点、胃排空以及迷走神经功能研究结果进行分析(受试者74%为女性,平均年龄43.1±15.4年),受试者接受了2次单光子发射计算机断层显像以评估GA和GE状态。胃容受性以餐后禁食胃体积比 (VR)为基础,对300名患者进行心电图分析以考察RSA症状。

研究发现,29.8%的参与者胃排空以及容受性正常,21.9%的患者存在胃容受性异常,27.1%的患者存在胃排空异常,21.1%的患者存在胃排空以及容受性异常。在胃排空正常、加快或延缓的患者中,其容受性存在差异(χ2P=0.062)。容受性增加(VR >3.85) 的现象在胃排空延缓的患者中更为普遍(14.0% vs. 6.8%, P=0.004),VR减少的现象 (平均减少2.9)在胃排空加快的患者中更为普遍。相比于胃排空加速以及正常的患者,胃排空延缓的患者更易出现恶心和呕吐的症状。呼吸窦性心律降低的患者其胃容受性减少的比例更高(41.5%)。多因素分析显示腹部不适症状与性别、体重指数、胃排空、糖尿病和腹部手术相关。

研究发现功能性胃十二指肠疾病患者存在一个或多个胃运动功能障碍和呼吸窦性心律降低。对于胃运动功能异常的患者,呕吐表明患者可能存在胃排空延缓,呼吸窦性心律降低预示患者可能存在胃容受性降低。

原始出处:

Seon-Young Park et al. Gastric Motor Dysfunction in Patients With Functional Gastroduodenal Symptoms. Am J Gastroenterol. September 12 2017.

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    2018-03-01 许安
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  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244720, encodeId=5fa1244e202f, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sat Sep 16 21:14:16 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1696531, encodeId=f5591696531fa, content=<a href='/topic/show?id=2c5194149af' target=_blank style='color:#2F92EE;'>#运动功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94149, encryptionId=2c5194149af, topicName=运动功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce9629890329, createdName=doctor-chen9592, createdTime=Thu Feb 22 09:43:00 CST 2018, time=2018-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1900680, encodeId=edc11900680f1, content=<a href='/topic/show?id=4e0c3566952' target=_blank style='color:#2F92EE;'>#十二指肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35669, encryptionId=4e0c3566952, topicName=十二指肠)], attachment=null, authenticateStatus=null, createdAvatar=, 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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244720, encodeId=5fa1244e202f, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sat Sep 16 21:14:16 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-21 cscdliu

    文章很好.谢谢.学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1696531, encodeId=f5591696531fa, content=<a href='/topic/show?id=2c5194149af' target=_blank style='color:#2F92EE;'>#运动功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94149, encryptionId=2c5194149af, topicName=运动功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce9629890329, createdName=doctor-chen9592, createdTime=Thu Feb 22 09:43:00 CST 2018, time=2018-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1900680, encodeId=edc11900680f1, content=<a href='/topic/show?id=4e0c3566952' target=_blank style='color:#2F92EE;'>#十二指肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35669, encryptionId=4e0c3566952, topicName=十二指肠)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7460166, createdName=zhang92560, createdTime=Tue Mar 20 22:43:00 CST 2018, time=2018-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071906, encodeId=a28920e19061a, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Thu Mar 01 10:43:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064199, encodeId=aec220641990c, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Jul 20 02:43:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809243, encodeId=929e1809243e1, content=<a href='/topic/show?id=91ea831e011' target=_blank style='color:#2F92EE;'>#胃十二指肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83170, encryptionId=91ea831e011, topicName=胃十二指肠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac782500066, createdName=12498768m13(暂无昵称), createdTime=Sat Apr 07 08:43:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711195, encodeId=35861e1119569, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Apr 13 02:43:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246309, encodeId=c7cb24630994, content=文章很好.谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Thu Sep 21 11:58:45 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421101, encodeId=bdf4142110150, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Sun Sep 17 23:43:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244978, encodeId=9b6c2449e8bf, content=文章很好.赞赞赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 17 11:23:44 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244720, encodeId=5fa1244e202f, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sat Sep 16 21:14:16 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1696531, encodeId=f5591696531fa, content=<a href='/topic/show?id=2c5194149af' target=_blank style='color:#2F92EE;'>#运动功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94149, encryptionId=2c5194149af, topicName=运动功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce9629890329, createdName=doctor-chen9592, createdTime=Thu Feb 22 09:43:00 CST 2018, time=2018-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1900680, encodeId=edc11900680f1, content=<a href='/topic/show?id=4e0c3566952' target=_blank style='color:#2F92EE;'>#十二指肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35669, encryptionId=4e0c3566952, topicName=十二指肠)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7460166, createdName=zhang92560, createdTime=Tue Mar 20 22:43:00 CST 2018, time=2018-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071906, encodeId=a28920e19061a, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Thu Mar 01 10:43:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064199, encodeId=aec220641990c, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Jul 20 02:43:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809243, encodeId=929e1809243e1, content=<a href='/topic/show?id=91ea831e011' target=_blank style='color:#2F92EE;'>#胃十二指肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83170, encryptionId=91ea831e011, topicName=胃十二指肠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac782500066, createdName=12498768m13(暂无昵称), createdTime=Sat Apr 07 08:43:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711195, encodeId=35861e1119569, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Apr 13 02:43:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246309, encodeId=c7cb24630994, content=文章很好.谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Thu Sep 21 11:58:45 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421101, encodeId=bdf4142110150, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Sun Sep 17 23:43:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244978, encodeId=9b6c2449e8bf, content=文章很好.赞赞赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 17 11:23:44 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244720, encodeId=5fa1244e202f, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sat Sep 16 21:14:16 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-17 1e10c84am36(暂无匿称)

    文章很好.赞赞赞

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1696531, encodeId=f5591696531fa, content=<a href='/topic/show?id=2c5194149af' target=_blank style='color:#2F92EE;'>#运动功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94149, encryptionId=2c5194149af, topicName=运动功能)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce9629890329, createdName=doctor-chen9592, createdTime=Thu Feb 22 09:43:00 CST 2018, time=2018-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1900680, encodeId=edc11900680f1, content=<a href='/topic/show?id=4e0c3566952' target=_blank style='color:#2F92EE;'>#十二指肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=35669, encryptionId=4e0c3566952, topicName=十二指肠)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7460166, createdName=zhang92560, createdTime=Tue Mar 20 22:43:00 CST 2018, time=2018-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071906, encodeId=a28920e19061a, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Thu Mar 01 10:43:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2064199, encodeId=aec220641990c, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Jul 20 02:43:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809243, encodeId=929e1809243e1, content=<a href='/topic/show?id=91ea831e011' target=_blank style='color:#2F92EE;'>#胃十二指肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83170, encryptionId=91ea831e011, topicName=胃十二指肠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac782500066, createdName=12498768m13(暂无昵称), createdTime=Sat Apr 07 08:43:00 CST 2018, time=2018-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1711195, encodeId=35861e1119569, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Fri Apr 13 02:43:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=246309, encodeId=c7cb24630994, content=文章很好.谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/23/557c1f19aaf5459a8405411e38903c4b.jpg, createdBy=dfc02088287, createdName=cscdliu, createdTime=Thu Sep 21 11:58:45 CST 2017, time=2017-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421101, encodeId=bdf4142110150, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Sun Sep 17 23:43:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244978, encodeId=9b6c2449e8bf, content=文章很好.赞赞赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 17 11:23:44 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=244720, encodeId=5fa1244e202f, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Sat Sep 16 21:14:16 CST 2017, time=2017-09-16, status=1, ipAttribution=)]
    2017-09-16 thlabcde

    好资料学习了!

    0

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