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帕金森症药物（ITI-214）可能对心力衰竭患者有效

2018-07-28 MedSci MedSci原创

ITI-214帕金森症心力衰竭
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一类名为磷酸二酯酶（PDE）I型抑制剂的化合物（ITI-214）目前正处于治疗帕金森病的临床试验中，并显示出犬和兔心脏肌肉收缩强度的增加，预示着该药物不仅对帕金森症有效，有可能对心力衰竭患者同样有效。约翰斯霍普金斯大学的研究人员对该药物的作用进行了体内研究，现在正处于早期临床试验阶段。

一类名为磷酸二酯酶（PDE）I型抑制剂的化合物（ITI-214）目前正处于治疗帕金森病的临床试验中，并显示出犬和兔心脏肌肉收缩强度的增加，预示着该药物不仅对帕金森症有效，有可能对心力衰竭患者同样有效。约翰斯霍普金斯大学的研究人员对该药物的作用进行了体内研究，现在正处于早期临床试验阶段。

目前有许多药物可用于治疗心力衰竭，但是那些加强心肌收缩的药物会带来危险的副作用，例如心律不齐的产生。目前正在进行临床试验证明，ITI-214抑制PDE，而PDE是一种分解细胞内其他信使分子的酶。该团队最初在小鼠身上测试药物，其后决定对狗、兔和分离的兔心脏细胞进行测试，因为已知PDE酶在人类中的形式与小鼠中的形式大不相同。

口服剂量为每公斤体重10毫克，该药物使健康心脏中泵出血液量增加了50％。在心力衰竭的模型中，使心脏中泵出血液量增加了30％。当静脉内给药时，该药物具有相似但更快的效果。


原始出处：

https://www.europeanpharmaceuticalreview.com/news/77525/parkinsons-drug-heart-failure/

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    2018-08-04 liumin1987

    帕金森药物对心衰的作用。

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=336293, encodeId=213c33629328, content=帕金森药物对心衰的作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Sat Aug 04 10:32:52 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518874, encodeId=01b115188e4d1, content=<a href='/topic/show?id=2ad14853585' target=_blank style='color:#2F92EE;'>#帕金森症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48535, encryptionId=2ad14853585, topicName=帕金森症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b6811200125, createdName=howi, createdTime=Mon Jul 30 01:39:00 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334712, encodeId=b2dc334e1262, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Jul 28 11:16:20 CST 2018, time=2018-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334703, encodeId=8a58334e03ba, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRvvXNvY0kOJqn4liar3Q6V6yPuEIawCVUyP3jVADh5icIz0ibrsxia6fKAqKsDr33jPWrjqM3D7wcRNu/0, createdBy=5a881701729, createdName=小树熊, createdTime=Sat Jul 28 11:05:51 CST 2018, time=2018-07-28, status=1, ipAttribution=)]
    2018-07-30 howi

    #帕金森症#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=336293, encodeId=213c33629328, content=帕金森药物对心衰的作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Sat Aug 04 10:32:52 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518874, encodeId=01b115188e4d1, content=<a href='/topic/show?id=2ad14853585' target=_blank style='color:#2F92EE;'>#帕金森症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48535, encryptionId=2ad14853585, topicName=帕金森症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b6811200125, createdName=howi, createdTime=Mon Jul 30 01:39:00 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334712, encodeId=b2dc334e1262, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Jul 28 11:16:20 CST 2018, time=2018-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334703, encodeId=8a58334e03ba, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRvvXNvY0kOJqn4liar3Q6V6yPuEIawCVUyP3jVADh5icIz0ibrsxia6fKAqKsDr33jPWrjqM3D7wcRNu/0, createdBy=5a881701729, createdName=小树熊, createdTime=Sat Jul 28 11:05:51 CST 2018, time=2018-07-28, status=1, ipAttribution=)]
    2018-07-28 医者仁心5538

    学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=336293, encodeId=213c33629328, content=帕金森药物对心衰的作用。, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/07/16/3b24606172648eea459125cb74754afe.jpg, createdBy=6c022216608, createdName=liumin1987, createdTime=Sat Aug 04 10:32:52 CST 2018, time=2018-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518874, encodeId=01b115188e4d1, content=<a href='/topic/show?id=2ad14853585' target=_blank style='color:#2F92EE;'>#帕金森症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48535, encryptionId=2ad14853585, topicName=帕金森症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6b6811200125, createdName=howi, createdTime=Mon Jul 30 01:39:00 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334712, encodeId=b2dc334e1262, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Sat Jul 28 11:16:20 CST 2018, time=2018-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=334703, encodeId=8a58334e03ba, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRvvXNvY0kOJqn4liar3Q6V6yPuEIawCVUyP3jVADh5icIz0ibrsxia6fKAqKsDr33jPWrjqM3D7wcRNu/0, createdBy=5a881701729, createdName=小树熊, createdTime=Sat Jul 28 11:05:51 CST 2018, time=2018-07-28, status=1, ipAttribution=)]
    2018-07-28 小树熊

    学习了

    0

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