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Clin Infect Dis:孕期前28周接受抗梅毒治疗可大幅减少先天梅毒的发生

2017-05-08 MedSci MedSci原创

梅毒孕妇早期治疗对于预防胎儿先天性传播来说是至关重要的。来自中国深圳慢性病控制中心的研究人员发现,妊娠第28周之前使用苄星青霉素G可有效预防梅毒先天性传播,该研究结果已发表于Clinical Infectious Diseases。 研究人员收集了来自中国国家综合方案对预防艾滋病、梅毒和乙型肝炎母婴传播的数据,结果发现在广东深圳共有3519名婴儿其母亲孕期诊断为梅毒患者梅毒。 其中15

梅毒孕妇早期治疗对于预防胎儿先天性传播来说是至关重要的。来自中国深圳慢性病控制中心的研究人员发现,妊娠第28周之前使用苄星青霉素G可有效预防梅毒先天性传播,该研究结果已发表于Clinical Infectious Diseases。

研究人员收集了来自中国国家综合方案对预防艾滋病、梅毒和乙型肝炎母婴传播的数据,结果发现在广东深圳共有3519名婴儿其母亲孕期诊断为梅毒患者梅毒。

其中159名(4.52%)婴儿诊断为先天梅毒。6名婴儿的母亲孕期前28周接受了BPG治疗(早期BPG),11名婴儿的母亲在其妊娠28周后接受BPG(晚期BPG),1名婴儿的母亲接受了其他的抗生素治疗,141名婴儿的母亲未接受任何的梅毒治疗。

与接受晚期BPG治疗(aOR 8.06,P<0.001),接受另一种抗生素治疗(aOR 7.71,P =0. 068)以及未接受任何治疗(aOR 68.28,P<0.001)相比,接受早期BPG治疗的母亲,婴儿先天性梅毒的发病率低1.82%~11.9%。

研究人员估计,梅毒女性孕期若未接受治疗,则每100个新生儿中便有12.23名患有先天梅毒。

对于只有小学或以下教育程度的女性(aOR 1.5),深圳居民女性(AOR 1.38),在欠发达地区接受产前护理(aOR 1.62),孕期第28周或以后接受首次产前护理(aOR 21.47),HIV感染者(aOR 4.01),以及孕前接受抗梅毒治疗的女性(aOR 1.65)放弃或错过梅毒治疗的可能性较高。

研究人员表示,这些发现可作为指导预防梅毒母婴传播的研究证据,并更新WHO制定的用于评估因母体梅毒导致不良妊娠结局的疾病负担的工具。

原始出处:


SHOW CITATION. Syphilis treatment in mothers crucial to preventing congenital infection. Healio, May 8, 2017.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2012243, encodeId=2b65201224356, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Aug 09 08:34:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199217, encodeId=c4c019921e3f, content=现在梅毒,病人咋那么多,, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Wed May 17 12:37:24 CST 2017, time=2017-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197967, encodeId=0a5c19e9674c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Sun May 14 12:30:29 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195500, encodeId=c73f195500e4, content=其实预防先天性梅毒最关键的是早起发现,我国还有好多地方孕期都没有发现妈妈有梅毒,妇女儿童健康事业还在路上, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7lBrMCuvxicCR3XJQhu2X3SmEzicSFDknz19Vav0ln3PHYSicIKQRIiazzcibtEchpeQNrjh2jfOYC0w/132, createdBy=eb931929187, createdName=美丽明天在等我, createdTime=Mon May 08 21:59:28 CST 2017, time=2017-05-08, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2012243, encodeId=2b65201224356, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Aug 09 08:34:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199217, encodeId=c4c019921e3f, content=现在梅毒,病人咋那么多,, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Wed May 17 12:37:24 CST 2017, time=2017-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197967, encodeId=0a5c19e9674c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Sun May 14 12:30:29 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195500, encodeId=c73f195500e4, content=其实预防先天性梅毒最关键的是早起发现,我国还有好多地方孕期都没有发现妈妈有梅毒,妇女儿童健康事业还在路上, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7lBrMCuvxicCR3XJQhu2X3SmEzicSFDknz19Vav0ln3PHYSicIKQRIiazzcibtEchpeQNrjh2jfOYC0w/132, createdBy=eb931929187, createdName=美丽明天在等我, createdTime=Mon May 08 21:59:28 CST 2017, time=2017-05-08, status=1, ipAttribution=)]
    2017-05-17 微笑人参

    现在梅毒,病人咋那么多,

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2012243, encodeId=2b65201224356, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Aug 09 08:34:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199217, encodeId=c4c019921e3f, content=现在梅毒,病人咋那么多,, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Wed May 17 12:37:24 CST 2017, time=2017-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197967, encodeId=0a5c19e9674c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Sun May 14 12:30:29 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195500, encodeId=c73f195500e4, content=其实预防先天性梅毒最关键的是早起发现,我国还有好多地方孕期都没有发现妈妈有梅毒,妇女儿童健康事业还在路上, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7lBrMCuvxicCR3XJQhu2X3SmEzicSFDknz19Vav0ln3PHYSicIKQRIiazzcibtEchpeQNrjh2jfOYC0w/132, createdBy=eb931929187, createdName=美丽明天在等我, createdTime=Mon May 08 21:59:28 CST 2017, time=2017-05-08, status=1, ipAttribution=)]
    2017-05-14 lou.minghong

    学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2012243, encodeId=2b65201224356, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Aug 09 08:34:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199217, encodeId=c4c019921e3f, content=现在梅毒,病人咋那么多,, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220317/1c3b2db4747d42e88e5018b394979434/be0fcebf07344e9ab886c37c502e2f29.jpg, createdBy=6bb22051299, createdName=微笑人参, createdTime=Wed May 17 12:37:24 CST 2017, time=2017-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=197967, encodeId=0a5c19e9674c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Sun May 14 12:30:29 CST 2017, time=2017-05-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=195500, encodeId=c73f195500e4, content=其实预防先天性梅毒最关键的是早起发现,我国还有好多地方孕期都没有发现妈妈有梅毒,妇女儿童健康事业还在路上, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/DYAIOgq83er7lBrMCuvxicCR3XJQhu2X3SmEzicSFDknz19Vav0ln3PHYSicIKQRIiazzcibtEchpeQNrjh2jfOYC0w/132, createdBy=eb931929187, createdName=美丽明天在等我, createdTime=Mon May 08 21:59:28 CST 2017, time=2017-05-08, status=1, ipAttribution=)]
    2017-05-08 美丽明天在等我

    其实预防先天性梅毒最关键的是早起发现,我国还有好多地方孕期都没有发现妈妈有梅毒,妇女儿童健康事业还在路上

    0

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