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Dig Dis Sci: 炎症性肠病合并糖尿病可预测不良疾病相关结果和感染并发症的发生

2021-07-14 MedSci原创 MedSci原创

糖尿病 (DM) 和炎症性肠病 (IBD) 是与慢性炎症、生态失调、免疫功能受损和感染风险相关的慢性全身性疾病。DM 在改变 IBD 患者疾病活动方面的影响在

      糖尿病 (DM) 和炎症性肠病 (IBD) 是与慢性炎症、生态失调、免疫功能受损和感染风险相关的慢性全身性疾病。DM 在改变 IBD 患者疾病活动方面的影响在很大程度上仍然未知。因此,本项研究旨在对DM对IBD 患者的相关疾病结局、死亡率和感染的影响进行研究。

 

      本项研究是一项纵向队列分析。使用大型机构数据库确定并收集了被诊断为IBD 和 DM(IBD-DM)和不伴 DM 的 IBD(IBD 队列)的患者,并纵向跟踪以评估主要(IBD 相关)和次要(死亡率和感染)结果。Cox 比例风险模型用于确定 DM 对每个结果的独立影响。

 

      IBD-DM和DM队列中分别包括了 901和1584名患者。与 IBD患者相比,IBD-DM患者具有显着更高的 IBD 相关住院风险 [ (HR) 1.97,95% CI(1.71–2.28)]、疾病复发几率 [HR 2.05 (1.75–2.39)] 和并发症发生率[HR 1.54 (1.29–1.85)]。IBD相关手术的发生率没有观察到显着差异。全因死亡率、败血症、艰难梭菌感染 (CDI)、肺炎、尿路感染和皮肤感染在 IBD-DM 中也比 IBD 队列更常见(p≤ 0.05)。克罗恩病 (CD) 和溃疡性结肠炎患者的亚组分析显示出相似的关联。

图:患者纳排示意图

      本项研究证实IBD 患者合并糖尿病是不良疾病相关结局和感染结局的预测指标。

 

 

原始出处:

Anand Kumar. Et al. Comorbid Diabetes in Inflammatory Bowel Disease Predicts Adverse Disease-Related Outcomes and Infectious Complications. Digestive Diseases and Sciences.2021.

 

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    2021-11-08 丁鹏鹏
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    2021-06-28 misszhang

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