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J Hypertens:高血压患者脑小血管病变MRI进展与认知功能下降有何关系?

2017-05-21 xing.T MedSci原创

在高血压患者中,为期4年的脑室周围WMH进展与认知能力下降有关,而基线脑室周围WMH和认知能力的下降之间无相关性。这些结果强调了预防高血压患者WMH进展的重要性。

高血压与认知功能障碍相关,可能是因为它是白质高信号(WMH)、腔隙、脑微出血发生发展的一个主要危险因素,这些变化是脑小血管病变的MRI标记。研究这些MRI标记的存在或进展与高血压患者的认知能力下降之间的相关性较少。近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员旨在评估高血压患者4年期间基础存在的和进展的脑小血管病变MRI标志与认知功能下降之间的相关性。

在这项纵向研究中,高血压患者在基线和4年后进行了神经心理学评估和大脑MRI检查。对脑室周围白质和皮质下脑白质、腔隙和脑微出血的存在和进展进行了可视化评估。

该研究共纳入了128例原发性高血压患者(90例原发性高血压患者和38例高血压腔隙性卒中患者),平均年龄为58.6±12.2岁。在简单回归分析中(P=0.001)和在校正了基线WMH存在和潜在混杂因素的多变量分析中(P=0.004),脑室周围WMH进展与认知能力下降相关。在多变量分析中,脑室周围WMH进展的R2为5.6%,而基线室周WMH存在的R2为0.6%。研究人员没有发现其他MRI标记的基线存在和进展与认知能力下降之间存在显著的相关性。

在高血压患者中,为期4年的脑室周围WMH进展与认知能力下降有关,而基线脑室周围WMH和认知能力的下降之间无相关性。这些结果强调了预防高血压患者WMH进展的重要性。

原始出处:

Uiterwijk, Renske.et al. MRI progression of cerebral small vessel disease and cognitive decline in patients with hypertension.Journal of Hypertension. 2017. http://journals.lww.com/jhypertension/Abstract/2017/06000/MRI_progression_of_cerebral_small_vessel_disease.19.aspx

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target=_blank style='color:#2F92EE;'>#脑小血管病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84828, encryptionId=87068482845, topicName=脑小血管病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=68f2317, createdName=天堂的云, createdTime=Tue May 23 02:33:00 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1391065, encodeId=43f313910659a, content=<a href='/topic/show?id=6d0689e19f0' target=_blank style='color:#2F92EE;'>#血管病变#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89719, encryptionId=6d0689e19f0, topicName=血管病变)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85152500072, createdName=124987c6m36暂无昵称, createdTime=Tue May 23 02:33:00 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448183, encodeId=86071448183e9, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Tue May 23 02:33:00 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2018-01-29 feather89
  5. 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  6. 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GetPortalCommentsPageByObjectIdResponse(id=1448183, encodeId=86071448183e9, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Tue May 23 02:33:00 CST 2017, time=2017-05-23, status=1, ipAttribution=)]
    2017-06-11 jyzxjiangqin

    高血压患者的治疗。

    0

  7. 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    2017-05-27 139****7892

    0

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  9. 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5月17日是世界高血压日,自2014年起连续5年主题均为“知晓您的血压”。当天,高血压及相关疾病防控政策与实施研讨会在京举行。与会专家强调,提高知晓率是高血压防控的首要任务。要为血压检测提供最基本平台如血压测量屋,使公众获得更多血压筛查的机会和平台。

AIM:年轻人心血管疾病风险升高情况如何?大数据横断面研究告诉你

背景:美国心脏病学会和美国心脏学会(ACC/AHA) 的2013胆固醇管理指南推荐在所有20岁以上的成人中进行血脂筛查来识别动脉粥样硬化性心血管疾病(ASCVD)风险的增加。他汀类药物可被用于10年风险较高者(>5%) 或低密度脂蛋白胆固醇(LDL-C)水平≥4.92 mmol/L (190 mg/dL) 的患者。目的:本研究的目的是描述在小于50岁的非糖尿病成人中,心血管疾病风险升高的发生

J Hypertens:高钠摄入的高血压人群降压治疗选择替米沙坦还是氢氯噻嗪?

由此可见,替米沙坦和氢氯噻嗪都是高钠摄入量的高血压患者有效地治疗药物。相比于氢氯噻嗪,替米沙坦具有更好的舒张压降低效果和较少的低血钾。需要进一步的研究以评估PP较大的患者氢氯噻嗪合理的优势效果。

世界高血压日:高血压最可怕的症状是哪种?

指导专家:和渝斌,中国人民解放军陆军总医院心肺血管中心主任欧阳平,南方医科大学中西医结合医院心血管科主任孙宁玲,北京大学人民医院心脏中心副主任赵统兵,深圳市第二人民医院心内科主任5月17日是世界高血压日,高血压被称为危害居民健康和生命的“无声杀手”。目前,我国高血压患病率高达25.2%,每四个成年人就有一人患高血压。不过不要怕,国内外经验表明,高血压是可防可控的疾病,关键在于有没有及时监测和控制~

Circulation:强化降低血压对高血压患者左心室肥厚的影响!

目前尚不清楚超出推荐值的强化血压(BP)降低是否会导致高血压患者的左心室肥大(LVH)风险降低;也尚不清楚,LVH的风险降低是否可以解释在这个人群中所报告的对心血管疾病( CVD)的益处。近期,一项发表在杂志Circulation上的研究分析了8,164名具有高血压但无糖尿病的参与者(平均年龄67.9岁,女性35.3%,31.2%黑人)的收缩期血压干预(SPRINT)试验;4,086名参与者随机分

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