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新型抗TNFα抗体片段治疗眼前段炎症

2019-01-06 MedSci MedSci原创

Oculis是一家开发下一代局部眼科治疗药物的临床阶段生物制药公司,Oculis已签署协议,授权诺华公司推出一种新型局部抗TNFα抗体,该化合物名为LME 636,由专有的局部递送单链抗体片段技术给药。

Oculis是一家开发下一代局部眼科治疗药物的临床阶段生物制药公司,Oculis已签署协议,授权诺华公司推出一种新型局部抗TNFα抗体,该化合物名为LME 636,由专有的局部递送单链抗体片段技术给药。在诺华生物医学研究所进行的三项临床试验显示了LME 636的有效性和安全性,这些研究证明了LME 636可以用于治疗眼前段炎症,包括干眼症。眼前段包括角膜,巩膜、虹膜等,此部分炎症如果影响房角组织,或炎症渗出影响房水成分,都会使房水外流受阻,最终导致眼压升高。

肿瘤坏死因子 αTNFα 是一种多功能细胞因子,参与细胞的凋亡和存活、炎症反应、自身免疫等重要的生理过程,在类风湿性关节炎、克罗恩病和银屑病等疾病的发生发展中扮演重要角色。这使得靶向 TNFα 的治疗性药物研发成为这些疾病防治研究领域的热点,其中尤以抗TNFα抗体的效果最为显著。但在眼科炎症领域,对抗TNFα抗体的研究较少,而LME 636有可能成为第一款用于眼科炎症的抗TNFα抗体片段。


原始出处:

http://www.firstwordpharma.com/node/1615878?tsid=4#axzz5bnF206kJ

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    2019-11-03 gongliu
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    2019-02-01 mfx808
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    2019-01-08 snowpeakxu
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