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Sci Rep：研究揭示糖皮质激素可调节去神经支配诱导骨形成减少的机制

2017-09-05 MedSci MedSci原创

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成人和儿童的去神经支配都可抑制骨生长和重塑，导致线性生长和骨量改变，并增加骨质疏松和病理性骨折的风险。转化生长因子β（TGF-β）亚型是促进骨形成的一组关键生长因子。本探究旨在探究去神经支配诱导骨形成减少与TGF-β基因表达之间的关系。研究人员测定了去神经支配小鼠骨中TGF-β的mRNA水平。结果发现，TGF-β1、TGF-β2和TGF-β3的mRNA水平降低。这些变化伴随着体重、骨密度（BMD）

成人和儿童的去神经支配都可抑制骨生长和重塑，导致线性生长和骨量改变，并增加骨质疏松和病理性骨折的风险。转化生长因子β（TGF-β）亚型是促进骨形成的一组关键生长因子。本探究旨在探究去神经支配诱导骨形成减少与TGF-β基因表达之间的关系。

研究人员测定了去神经支配小鼠骨中TGF-β的mRNA水平。结果发现，TGF-β1、TGF-β2和TGF-β3的mRNA水平降低。这些变化伴随着体重、骨密度（BMD）、骨小梁厚度、骨小梁分离、股骨和腰椎骨小梁数量、血清骨钙素、总钙以及甲状旁腺激素的减少，而血清C肽水平增加。

重组人转化生长因子β1(rhTGF-β1)可防止去神经支配引起的骨密度降低，进一步研究支持去神经支配诱导骨形成的减少是由于抑制TGF-β基因表达减少所致。此外，抗孕激素RU 38486干扰去神经支配引起的TGF-βmRNA表达水平的降低，而地塞米松（DEX）可降低正常小鼠TGF-βmRNA的水平。研究哈发现，去神经支配小鼠血浆皮质酮增加了三倍。

总之，这些结果表明，糖皮质激素或可通过抑制TGF-β基因的表达来调节去神经支配诱导骨形成的减少。

原始出处：

Ye Li, Ligang Jie, Austin Y. Tian, et al., Transforming Growth Factor Beta is regulated by a Glucocorticoid-Dependent Mechanism in Denervation Mouse Bone. Sci Rep. 2017; 7: 9925. Published online 2017 Aug 30. doi: 10.1038/s41598-017-09793-y.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1701175, encodeId=6bda1e0117524, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Mon Jul 30 03:33:00 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600285, encodeId=5046160028564, content=<a href='/topic/show?id=3565e21649e' target=_blank style='color:#2F92EE;'>#皮质激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72164, encryptionId=3565e21649e, topicName=皮质激素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb1a18781011, createdName=bbwznl, createdTime=Thu Sep 07 13:33:00 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240987, encodeId=e42a24098eff, content=学习了学习了学习了学习了学习了学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Wed Sep 06 09:26:54 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240863, encodeId=5af4240863cc, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Sep 05 23:41:30 CST 2017, time=2017-09-05, status=1, ipAttribution=)]
    2018-07-30 Tommy1959

    #糖皮质#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1701175, encodeId=6bda1e0117524, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Mon Jul 30 03:33:00 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600285, encodeId=5046160028564, content=<a href='/topic/show?id=3565e21649e' target=_blank style='color:#2F92EE;'>#皮质激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72164, encryptionId=3565e21649e, topicName=皮质激素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb1a18781011, createdName=bbwznl, createdTime=Thu Sep 07 13:33:00 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240987, encodeId=e42a24098eff, content=学习了学习了学习了学习了学习了学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Wed Sep 06 09:26:54 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240863, encodeId=5af4240863cc, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Sep 05 23:41:30 CST 2017, time=2017-09-05, status=1, ipAttribution=)]
    2017-09-07 bbwznl

    #皮质激素#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1701175, encodeId=6bda1e0117524, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Mon Jul 30 03:33:00 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600285, encodeId=5046160028564, content=<a href='/topic/show?id=3565e21649e' target=_blank style='color:#2F92EE;'>#皮质激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72164, encryptionId=3565e21649e, topicName=皮质激素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb1a18781011, createdName=bbwznl, createdTime=Thu Sep 07 13:33:00 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240987, encodeId=e42a24098eff, content=学习了学习了学习了学习了学习了学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Wed Sep 06 09:26:54 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240863, encodeId=5af4240863cc, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Sep 05 23:41:30 CST 2017, time=2017-09-05, status=1, ipAttribution=)]
    2017-09-06 hfuym10906

    学习了学习了学习了学习了学习了学习了学习了

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1701175, encodeId=6bda1e0117524, content=<a href='/topic/show?id=b5f6e6827fb' target=_blank style='color:#2F92EE;'>#糖皮质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76827, encryptionId=b5f6e6827fb, topicName=糖皮质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f4230340116, createdName=Tommy1959, createdTime=Mon Jul 30 03:33:00 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1600285, encodeId=5046160028564, content=<a href='/topic/show?id=3565e21649e' target=_blank style='color:#2F92EE;'>#皮质激素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72164, encryptionId=3565e21649e, topicName=皮质激素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb1a18781011, createdName=bbwznl, createdTime=Thu Sep 07 13:33:00 CST 2017, time=2017-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240987, encodeId=e42a24098eff, content=学习了学习了学习了学习了学习了学习了学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuIjZYTAgkEia1SFuoeAByVaQC8uXegibpJEV2Q7SqhpDINJicNiaU5pYicYmy5WsI8l5hDribViac2A1BQ9/0, createdBy=c36f1724608, createdName=hfuym10906, createdTime=Wed Sep 06 09:26:54 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=240863, encodeId=5af4240863cc, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Sep 05 23:41:30 CST 2017, time=2017-09-05, status=1, ipAttribution=)]
    2017-09-05 惠映实验室

    学习了.谢谢.

    0

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