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JAHA:口服抗凝治疗与左心耳封堵对房颤患者认知功能和生活质量的影响

2021-04-20 MedSci原创 MedSci原创

在接受LAAO的消融后房颤患者与仍接受OAC的房颤患者中,术后MoCA评分存在显著差异。OAC组的得分有所下降,但是各组的生活质量都有类似的改善。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员比较了接受左心耳闭塞(LAAO)或房颤消融后仍接受口服抗凝(OAC)的房颤患者认知状态和生活质量。

研究人员通过蒙特利尔认知评估(MoCA)调查来评估的基线和随访期间受试者的认知功能,并筛选了连续就诊的房颤消融后接受LAAO或OAC的患者,将得分≤17的患者排除在研究范围之外。研究人员使用房颤对生活质量影响的调查对参与者基线和1年时的生活质量进行测量。

该研究中LAAO组纳入了50例患者(CHA2DS2-VASc [充血性心力衰竭、高血压、年龄≥75岁、糖尿病卒中或短暂性脑缺血发作、血管疾病、年龄65-74岁、性别]评分:3.30±1.43),OAC组纳入了48例患者(CHA2DS2-VASc评分为2.73±1.25)。LAAO和OAC组的平均基线MoCA评分分别为26.18和26.08(P=0.846)。

在1年时,各个组的得分分别为26.94和23.38。OAC组的MoCA评分下降了约-2.74(95%CI为-3.61至-1.87; P<0.0001)分,而LAAO组变化无统计学意义(0.79;(95%CI为-0.06至1.64);P=0.07)。在调整了基线临床特征后,OAC上是1年时MoCA变化的独立预测因子(回归系数为-3.38;95%CI为-4.75至-2.02;P<0.0001)。房颤对生活质量评分的影响在两组之间的无显著差异。

由此可见,在接受LAAO的消融后房颤患者与仍接受OAC的房颤患者中,术后MoCA评分存在显著差异。OAC组的得分有所下降,但是各组的生活质量都有类似的改善

原始出处:

Sanghamitra Mohanty.et al.Impact of Oral Anticoagulation Therapy Versus Left Atrial Appendage Occlusion on Cognitive Function and Quality of Life in Patients With Atrial Fibrillation.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.019664

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    2021-04-22 zhaohui6731
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    2021-04-22 jxrzshh
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    2021-04-20 心介

    房颤,临床上碰到很多哦

    0

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