CLIN CANCER RES：乳腺癌患者循环肿瘤细胞的预后作用

2017-09-20 MedSci MedSci原创

CLIN CANCER RES近期发表了一篇文章，研究可手术或晚期乳腺癌患者接受新辅助治疗前和治疗后循环肿瘤细胞（CTC）对患者预后的影响。研究的患者来自GeparQuattro临床试验。

CLIN CANCER RES近期发表了一篇文章，研究可手术或晚期乳腺癌患者接受新辅助治疗前和治疗后循环肿瘤细胞（CTC）对患者预后的影响。研究的患者来自GeparQuattro临床试验。

新辅助治疗前有213例患者循环肿瘤细胞数据可用，治疗后有207例患者循环肿瘤细胞数据可用。利用K-M曲线及Cox模型分析循环肿瘤细胞与患者无病生存和总生存之间的关系。平均随访时间67.1个月。研究结果表明新辅助治疗前检测到≥1CTC/7.5ml和≥2CTC/7.5ml与无病生存和总生存降低有关，而新辅助治疗后检测到循环肿瘤细胞与无病生存或总生存无关。在单因素和多因素Cox分析中，≥1CTC/7.5ml，≥2CTCs/7.5ml和新辅助治疗前循环肿瘤细胞绝对数量是无病生存和总生存的独立预后因素。CTC阴性病理完全缓解（pCR）的患者预后最好，有循环肿瘤细胞的患者和肿瘤反应不良的患者复发风险高。在HER2阳性和三阴性患者中，新辅助治疗前检测到≥2CTCs/7.5ml与无病生存和总生存较差显着相关。

文章最后认为，新辅助治疗前检测到循环肿瘤细胞是独立预后因素，与pCR相结合可以帮助识别需要治疗干预的乳腺癌患者。

原始出处：

Sabine Riethdorf,Volkmar Muller,et al.Prognostic Impact of Circulating Tumor Cells for Breast Cancer Patients Treated in the Neoadjuvant "Geparquattro" Trial.CLIN CANCER RES.September 2017 doi:10.1158/1078-0432.CCR-17-0255

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2017-09-22 hmwwww

#肿瘤细胞#

42 0
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2017-09-22 hanhaisha2013

#乳腺癌患者#

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2017-09-22 thinkibmz_44722599

#循环肿瘤细胞#

50 0
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2017-09-21 一个字-牛

学习了谢谢分享

76 0
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2017-09-21 luominglian113

学习了.谢谢分享

86 0
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2017-09-20 zhutta

不错的结果!

68 0
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2017-09-20 lovetcm

我仅仅是循环的肿瘤细胞.而且是术后能不能获得CR同样重要

77 0
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2017-09-20 flysky120

癌症的治疗希望以后能治愈

78 0

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