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Clinica Chimica Acta:中国急性冠状动脉综合征患者非高密度脂蛋白胆固醇的目标需要调整:CCC-ACS项目的研究结果

2019-10-18 gladiator MedSci原创

指南建议将非高密度脂蛋白胆固醇(non-HDL-C)作为共同主要目标,并将非HDL-C目标设置为比低密度脂蛋白胆固醇(LDL-C)目标高30 µmg / dl。但在中国患者中,这一价值在很大程度上是不确定的。

指南建议将非高密度脂蛋白胆固醇non-HDL-C)作为共同主要目标,并将非HDL-C目标设置为比低密度脂蛋白胆固醇LDL-C)目标高30 µmg / dl。但在中国患者中,这一价值在很大程度上是不确定的。

我们为中国急性冠状动脉综合征(CCC-ACS)改善心血管疾病护理项目的患者分配了与LDL-C目标相对应的相同百分位数的非hdl - c值。我们计算了非hdl - cLDL-C之间的差异,并根据LDL-CTG浓度提出了合适的添加值。

研究发现,在73,495名患者中,有17.7%的患者在入院前使用了降脂药。 其中,27.2%的LDL-C <70μmg/ dl,而39.4%的非HDL-C <100μmg/ dl HDL-CLDL-C之间的平均差异为23.2μg/ dl,这可能受到LDL-CTG浓度的影响。 重要的是,对于LDL-C浓度≤100μg/ dl的患者,TG≤150μmg/ dl的患者的平均差异为19.1μg/ dl,而TG>150μmg/ dl的患者的平均差异为24.6μmg/ dl

中国ACS患者LDL-C与非hdl - c存在显著差异。对于二级预防,当LDL-C目标为70 ismg / dl时,TG≤150mg / dl的患者的平均添加值应为20 mg / dlTG> 150 mg / dl的患者的平均添加值应为25 / mg / dl

原始出处:

Xin Su,Mengdie Luo,Goals of non-high density lipoprotein cholesterol need to be adjusted in Chinese acute coronary syndrome patients: Findings from the CCC-ACS project

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    2020-01-07 windight
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channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84414, encryptionId=5a3b8441438, topicName=脂蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23ea3924919, createdName=juliusluan79, createdTime=Sun Oct 20 11:08:00 CST 2019, time=2019-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431653, encodeId=36fa143165301, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Oct 20 11:08:00 CST 2019, time=2019-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462987, encodeId=bd40146298ed3, content=<a href='/topic/show?id=53ad1023343a' target=_blank style='color:#2F92EE;'>#高密度脂蛋白胆固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102334, encryptionId=53ad1023343a, topicName=高密度脂蛋白胆固醇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0236523207, createdName=zchen, createdTime=Sun Oct 20 11:08:00 CST 2019, time=2019-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479248, encodeId=271914e924813, content=<a href='/topic/show?id=e01299e7076' target=_blank style='color:#2F92EE;'>#非高密度脂蛋白胆固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99770, encryptionId=e01299e7076, topicName=非高密度脂蛋白胆固醇)], 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  5. 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channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84414, encryptionId=5a3b8441438, topicName=脂蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23ea3924919, createdName=juliusluan79, createdTime=Sun Oct 20 11:08:00 CST 2019, time=2019-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431653, encodeId=36fa143165301, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Oct 20 11:08:00 CST 2019, time=2019-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462987, encodeId=bd40146298ed3, content=<a href='/topic/show?id=53ad1023343a' target=_blank style='color:#2F92EE;'>#高密度脂蛋白胆固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102334, encryptionId=53ad1023343a, topicName=高密度脂蛋白胆固醇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e0236523207, createdName=zchen, createdTime=Sun Oct 20 11:08:00 CST 2019, time=2019-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1479248, encodeId=271914e924813, content=<a href='/topic/show?id=e01299e7076' target=_blank style='color:#2F92EE;'>#非高密度脂蛋白胆固醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99770, encryptionId=e01299e7076, topicName=非高密度脂蛋白胆固醇)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b7a7505753, createdName=肉我只吃一口, createdTime=Sun Oct 20 11:08:00 CST 2019, time=2019-10-20, status=1, ipAttribution=)]
    2019-10-20 yaanren
  6. 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  7. 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