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Hypertension:AK098656,一种新长链非编码RNA,可促进高血压的发生和进展。

2018-01-01 MedSci MedSci原创

近期有研究报道一些长链非编码RNA(lncRNA)介导平滑肌细胞(VSMCs)表型转换(血管疾病的常见病理生理过程)。但人源性特异性表达的lncRNAs是否可调控VSMCs表型、又是否参与原发性高血压的致病机制都尚不清楚。通过与健康对照血液中的lncRNAs相比,研究人员发现高血压患者的血清中lncRNA-AK098656显着上调,而且主要表达于VSMCs。AK098656通过增强VSMC增殖和迁

近期有研究报道一些长链非编码RNA(lncRNA)介导平滑肌细胞(VSMCs)表型转换(血管疾病的常见病理生理过程)。但人源性特异性表达的lncRNAs是否可调控VSMCs表型、又是否参与原发性高血压的致病机制都尚不清楚。

通过与健康对照血液中的lncRNAs相比,研究人员发现高血压患者的血清中lncRNA-AK098656显着上调,而且主要表达于VSMCs。AK098656通过增强VSMC增殖和迁移、增加细胞外基质蛋白以及降低收缩蛋白来促进VSMCs呈现合成表型。

此外,还证实AK098656可直接与VSMCs特异性收缩蛋白(肌球蛋白重链-11)和细胞外基质的主要成分(纤连蛋白)直接结合,并通过蛋白质降解途径降低这些蛋白质水平。AK098656还与26S蛋白酶体非腺苷三磷酸调节亚基11相结合,促进高血压自然进展,伴随合成型VSMCs增多、阻力动脉变窄。转基因鼠表现为轻度的心肌肥大,无其他并发症,这一点与高血压早期病理生理性改变相似。

综上所述,AK098656,一种新的与VSMC匹配的lncRNA,可通过加速收缩蛋白降解、增加合成型VSMC了来促进高血压进展,并可促进阻力动脉变窄。

原始出处:

Ling Jin,et al.AK098656, a Novel Vascular Smooth Muscle Cell–Dominant Long Noncoding RNA, Promotes Hypertension.Hypertension. December 26,2017. https://doi.org/10.1161/HYPERTENSIONAHA.117.09651

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    2018-06-29 feather89
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    2018-09-16 yzh399
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    2018-02-25 d830384
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  5. 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  6. 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2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274622, encodeId=27202e4622aa, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Jan 02 05:54:12 CST 2018, time=2018-01-02, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1726967, encodeId=22461e2696797, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Jun 29 14:23:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779638, encodeId=81881e79638a0, content=<a href='/topic/show?id=97992228ab' target=_blank style='color:#2F92EE;'>#AK098656#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2228, encryptionId=97992228ab, topicName=AK098656)], attachment=null, authenticateStatus=null, createdAvatar=, 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2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274622, encodeId=27202e4622aa, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Jan 02 05:54:12 CST 2018, time=2018-01-02, status=1, ipAttribution=)]
    2018-01-02 天涯183

    非常好的文章.学习了

    0

  9. 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2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274622, encodeId=27202e4622aa, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Jan 02 05:54:12 CST 2018, time=2018-01-02, status=1, ipAttribution=)]
    2018-01-02 swfzhanggui

    非常好的文章.谢谢分享

    0

  10. 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2018, time=2018-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274622, encodeId=27202e4622aa, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Tue Jan 02 05:54:12 CST 2018, time=2018-01-02, status=1, ipAttribution=)]
    2018-01-02 yjs木玉

    好好好好好好好好

    0

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BMJ:降压药的递增效应研究

研究认为,对于心血管风险高但无糖尿病的高血压患者,额外的降压药物可降低动脉压以及心血管事件风险,该效果不受基础治疗方案以及疾病亚型的影响

Am J Obstet Gynecol: 降低妊娠期急性高血压:静脉注射肼屈嗪vs口服硝苯地平

2017年12月,发表在《Am J Obstet Gynecol》上的一项双盲、随机、对照试验,考察了妊娠期使用静脉注射肼屈嗪和口服硝苯地平进行急性血压控制的有效性。

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