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World Neurosurg:延髓深部海绵状血管畸形术后呼吸功能障碍的管理及危险因素

2018-08-12 MedSci MedSci原创

本研究旨在评估涉及延髓的海绵状畸形(CM)的手术治疗,并预测术后呼吸功能障碍(RDF)的危险因素。 采用回顾性研究设计,分析来自对涉及延髓的CM进行手术治疗的个体的患者数据。术后RDF和/或咳嗽反射缺陷(CR,≥7天)的患者被认为具有不良呼吸状态。二元逻辑回归分析测试了术前预测因子与不良术后呼吸状态的关联。 结果,纳入了69名患者。术前,9名患者(13.0%)患有呼吸困难,4名患者(5

本研究旨在评估涉及延髓的海绵状畸形(CM)的手术治疗,并预测术后呼吸功能障碍(RDF)的危险因素。

采用回顾性研究设计,分析来自对涉及延髓的CM进行手术治疗的个体的患者数据。术后RDF和/或咳嗽反射缺陷(CR,≥7天)的患者被认为具有不良呼吸状态。二元逻辑回归分析测试了术前预测因子与不良术后呼吸状态的关联。

结果,纳入了69名患者。术前,9名患者(13.0%)患有呼吸困难,4名患者(5.8%)患有低氧血症。术后,11名患者(15.9%)出现不良呼吸状态,其中6名患者出现RDF为呼吸紊乱和/或呼吸困难,5名患者出现≥7天的CR缺陷。平均随访时间为35.3个月,患者神经功能状态改善45例(68.2%),11例(16.7%)保持不变,10例(15.1%)相对于术前基线恶化。多因素Logistic回归分析发现,术后不良呼吸状态的独立不良因素为多发性术前出血,病变大,并且在慢性期(> 8周)内进行手术干预。

综上所述,该研究结果表明,术后RDF和CR缺陷通常发生在涉及延髓的CM患者中。然而,术前出血较少,病变范围较小以及最后一次出血后8周内手术的患者发生术后呼吸状况恶化的可能性降低。

原始出处:

Xie MG, Xiao XR, et al., Surgical Management and Risk Factors of Postoperative Respiratory Dysfunction of Cavernous Malformations Involving the Medulla Oblongata. World Neurosurg. 2018 Jul 20. pii: S1878-8750(18)31587-0. doi: 10.1016/j.wneu.2018.07.109. 

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1709726, encodeId=7de51e0972646, content=<a href='/topic/show?id=28e089e13d1' target=_blank style='color:#2F92EE;'>#血管畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89713, encryptionId=28e089e13d1, topicName=血管畸形)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=70cd31776816, createdName=12498ca5m93暂无昵称, createdTime=Thu Sep 06 19:51:00 CST 2018, time=2018-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1981465, encodeId=bb1f1981465ae, content=<a href='/topic/show?id=7bfb396288a' target=_blank style='color:#2F92EE;'>#呼吸功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39628, encryptionId=7bfb396288a, topicName=呼吸功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Mon Jan 28 09:51:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689837, encodeId=d037168983e2f, content=<a href='/topic/show?id=f86c4955e59' target=_blank style='color:#2F92EE;'>#延髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49557, encryptionId=f86c4955e59, topicName=延髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8c8428890315, createdName=446798725_87912774, createdTime=Thu Jul 11 04:51:00 CST 2019, time=2019-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362244, encodeId=8c5f13622441a, content=<a href='/topic/show?id=9857e03444b' target=_blank style='color:#2F92EE;'>#畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70344, encryptionId=9857e03444b, topicName=畸形)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Aug 14 10:51:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364367, encodeId=6fc1136436ee3, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Tue Aug 14 10:51:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421175, encodeId=494314211e5a0, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Tue Aug 14 10:51:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591774, encodeId=f1f61591e7484, content=<a href='/topic/show?id=3047656523d' target=_blank style='color:#2F92EE;'>#海绵状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65652, encryptionId=3047656523d, topicName=海绵状)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=223518012442, createdName=cooco, createdTime=Tue Aug 14 10:51:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=338427, encodeId=154c33842ed8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de4f1300985, createdName=wanghx2006, createdTime=Tue Aug 14 06:12:25 CST 2018, time=2018-08-14, status=1, ipAttribution=)]
    2018-08-14 lsndxfj
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  7. [GetPortalCommentsPageByObjectIdResponse(id=1709726, encodeId=7de51e0972646, content=<a href='/topic/show?id=28e089e13d1' target=_blank style='color:#2F92EE;'>#血管畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89713, encryptionId=28e089e13d1, topicName=血管畸形)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=70cd31776816, createdName=12498ca5m93暂无昵称, createdTime=Thu Sep 06 19:51:00 CST 2018, time=2018-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1981465, encodeId=bb1f1981465ae, content=<a href='/topic/show?id=7bfb396288a' target=_blank style='color:#2F92EE;'>#呼吸功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39628, encryptionId=7bfb396288a, topicName=呼吸功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Mon Jan 28 09:51:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689837, encodeId=d037168983e2f, content=<a href='/topic/show?id=f86c4955e59' target=_blank style='color:#2F92EE;'>#延髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49557, encryptionId=f86c4955e59, topicName=延髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8c8428890315, createdName=446798725_87912774, createdTime=Thu Jul 11 04:51:00 CST 2019, time=2019-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362244, encodeId=8c5f13622441a, content=<a href='/topic/show?id=9857e03444b' target=_blank style='color:#2F92EE;'>#畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70344, encryptionId=9857e03444b, topicName=畸形)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Aug 14 10:51:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364367, encodeId=6fc1136436ee3, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Tue Aug 14 10:51:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421175, encodeId=494314211e5a0, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Tue Aug 14 10:51:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591774, encodeId=f1f61591e7484, content=<a href='/topic/show?id=3047656523d' target=_blank style='color:#2F92EE;'>#海绵状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65652, encryptionId=3047656523d, topicName=海绵状)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=223518012442, createdName=cooco, createdTime=Tue Aug 14 10:51:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=338427, encodeId=154c33842ed8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de4f1300985, createdName=wanghx2006, createdTime=Tue Aug 14 06:12:25 CST 2018, time=2018-08-14, status=1, ipAttribution=)]
    2018-08-14 cooco
  8. [GetPortalCommentsPageByObjectIdResponse(id=1709726, encodeId=7de51e0972646, content=<a href='/topic/show?id=28e089e13d1' target=_blank style='color:#2F92EE;'>#血管畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89713, encryptionId=28e089e13d1, topicName=血管畸形)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=70cd31776816, createdName=12498ca5m93暂无昵称, createdTime=Thu Sep 06 19:51:00 CST 2018, time=2018-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1981465, encodeId=bb1f1981465ae, content=<a href='/topic/show?id=7bfb396288a' target=_blank style='color:#2F92EE;'>#呼吸功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39628, encryptionId=7bfb396288a, topicName=呼吸功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e6a1280, createdName=zhanglin3079, createdTime=Mon Jan 28 09:51:00 CST 2019, time=2019-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689837, encodeId=d037168983e2f, content=<a href='/topic/show?id=f86c4955e59' target=_blank style='color:#2F92EE;'>#延髓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49557, encryptionId=f86c4955e59, topicName=延髓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8c8428890315, createdName=446798725_87912774, createdTime=Thu Jul 11 04:51:00 CST 2019, time=2019-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1362244, encodeId=8c5f13622441a, content=<a href='/topic/show?id=9857e03444b' target=_blank style='color:#2F92EE;'>#畸形#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70344, encryptionId=9857e03444b, topicName=畸形)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Tue Aug 14 10:51:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364367, encodeId=6fc1136436ee3, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Tue Aug 14 10:51:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421175, encodeId=494314211e5a0, content=<a href='/topic/show?id=09d33294eb8' target=_blank style='color:#2F92EE;'>#功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32947, encryptionId=09d33294eb8, topicName=功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b3493649807, createdName=naiwu78, createdTime=Tue Aug 14 10:51:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591774, encodeId=f1f61591e7484, content=<a href='/topic/show?id=3047656523d' target=_blank style='color:#2F92EE;'>#海绵状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65652, encryptionId=3047656523d, topicName=海绵状)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=223518012442, createdName=cooco, createdTime=Tue Aug 14 10:51:00 CST 2018, time=2018-08-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=338427, encodeId=154c33842ed8, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=de4f1300985, createdName=wanghx2006, createdTime=Tue Aug 14 06:12:25 CST 2018, time=2018-08-14, status=1, ipAttribution=)]
    2018-08-14 wanghx2006

    学习

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