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Gastroenterol Res Pract:腹膜炎术后:降钙素原可指导抗生素治疗吗?

2017-07-02 MedSci MedSci原创

对于呼吸道感染的患者来说,血清降钙素原是指导抗生素治疗持续时间的有效生化学标志物。本研究的目的是确定PCT水平是否能为腹膜炎患者术后抗生素治疗提供指导。

对于呼吸道感染的患者来说,血清降钙素原是指导抗生素治疗持续时间的有效生化学标志物。本研究的目的是确定PCT水平是否能为腹膜炎患者术后抗生素治疗提供指导。

对腹膜炎术后患者进行随机分组。对照组根据指南在规定期限内接受抗生素治疗。在研究组中,根据血清PCT水平决定是否停止抗生素治疗。患者分为三类:(1)胃肠穿孔、(2)穿孔性阑尾炎、(3)术后并发症。主要研究结果为抗生素持续使用时间。

162名患者被纳入研究,对照组和研究组分别有83名和79名患者。在胃肠道穿孔腹膜炎患者亚组中,PCT指导组抗生素使用时间持续7天,对照组为10天(P=0.065)。在感染并发症、死亡率、住院天数和再次使用抗生素治疗等方面无明显差异。

由此我们可以得出结论:是否在PCT指导下抗生素,对抗生素使用总时间无显着差异。然而,在原发性胃肠道穿孔的亚组中,PCT组的抗生素使用持续时间并无显著差异,因为这项研究没有对亚组进行分析,所以应当进一步的对此亚组进行研究。

原始出处:

Slieker JC1, Aellen S2, et al. Procalcitonin-Guided Antibiotics after Surgery for Peritonitis: A Randomized Controlled Study. Gastroenterol Res Pract. 2017;2017:3457614. doi: 10.1155/2017/3457614. Epub 2017 May 16.

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JAMA Pediatr:降钙素原检测可识别发热婴儿是否存在严重细菌感染

CT测定比CRP测量检测7-91天的发热婴儿患有IBI具有更好的诊断准确度,PCT测定和CRP测量检测7-91天的发热婴儿患有SBI的效能相似。

The Lancet Infect Dis:评估ICU患者抗生素的使用及停药可依据降钙素原浓度

背景对于危重患者,使用抗生素治疗是非常重要的,但长期使用抗生素治疗增加患者的耐药性。降钙素原是一种用于指导抗菌治疗并减少其存在时间的标记物,但研究人员并不知道机体血清降钙素原减少的安全性。该研究旨在评估对ICU患者使用血清降钙素原指导抗生素使用的疗效和安全性。方式该研究为前瞻性、多中心、随机、对照、开放性研究。研究人员对荷兰15家医院18岁以上、既往出现感染或怀疑感染并首次使用抗生素不超过24小时

JAMA Intern Med:亚硒酸钠和PCT指导治疗不能改善脓毒症死亡率

根据最近的一项研究数据,高剂量的亚硒酸钠和基于血清降钙素原算法引导的抗感染治疗不能改善严重脓毒症患者的预后。Frank Bloos博士和同事在德国多个ICU进行了此项多中心随机安慰剂对照试验(SISPCT),随访90天。研究人员随机分配患者至亚硒酸钠静脉注射负荷剂量(1000克),随后亚硒酸钠每日持续静脉输注直至出院,但不再是21天;或分配到安慰剂组。患者随机接受血清降钙素原算法或无血清降钙素原的

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