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Neurology:阿替普酶治疗可降低缺血性卒中患者影像学进展风险

2018-10-29 zhangfan MedSci原创

研究认为阿替普酶治疗与短期缺血性卒中可见性病变进展风险降低相关,阿替普酶可通过减少组织损伤来改善功能结果

近日研究人员考察了阿替普酶治疗对脑影像学显示的脑卒中后缺血性病变进展的影响。

IST-3研究为考察阿替普酶治疗缺血性卒中的随机对照研究,在基线以及治疗后24-48小时对患者进行CT或MRI影像检查,考察急性病变的可见性、范围和肿胀程度,对治疗组和对照组进行治疗前后影像学变化的荟萃分析。

2916名患者接受基线及随访影像研究,病变范围或肿胀进展是6个月后不良预后的独立预测因素(范围进展OR=0.92,肿胀进展OR=0.73)。与对照组相比,接受阿替普酶治疗后患者随访过程中出现病变可见性增加风险降低(OR=0.77),但没有证据表明其对病变范围或肿胀进展的影响。总计包含4757患者的荟萃分析显示阿替普酶治疗与随访期间图像显示缺血病变程度减少有关(OR = 0.85)。

研究认为阿替普酶治疗与短期缺血性卒中可见性病变进展风险降低相关,阿替普酶可通过减少组织损伤来改善功能结果。

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    2019-02-18 yinhl1978
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    2018-10-29 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

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