Neurology：ALS患者的PET表现与认知障碍相关

2015-11-24 MedSci MedSci原创

研究显示ALS患者队列中连续的额叶代谢障碍反映了临床和解剖学上的疾病进展的过程，从单纯ALS、伴有中间认知缺陷的ALS到ALS-FTD。伴有中间认知障碍的ALS患者在PET检查下显示独特的代谢模式。

目的：使用18F-FDG-PET检查患者，识别ALS(amyotrophic
lateral sclerosis ，肌萎缩性脊髓侧索硬化症)不同层面的认知缺陷的代谢特征。

方法：研究共纳入170例在都灵ALS中心接受脑部18F-FDG-PET检查的ALS患者，根据根据神经心理测试分为ALS-Cn组(正常认知，n =94),组ALS-FTD (全面额颞叶痴呆，n = 20), ALS-Ci患者(认知障碍尚不满足FTD诊断标准，n =37),普遍行为变化患者(n = 9)或不可分类的认知障碍患者(n= 10)。在各个认知亚组中进行18F-FDG-PET检查，并将各组间18F-FDG-PET检查结果进行比较。

结果：研究发现ALS-FTD组与ALS-Cn组相比额叶和前额叶的新陈代谢明显减少，ALS-Ci组显示额叶皮质的中间代谢率与ALS-Cn组相比降低，与ALS-FTD组相比升高。

所有亚组中额叶代谢减退与小脑、中脑和皮质脊髓束代谢亢进相关。认知能力下降越严重，PET显示代谢减低的脑区面积越大，18F-FDG摄取的统计学差异越大。

结论：研究显示ALS患者队列中连续的额叶代谢障碍反映了临床和解剖学上的疾病进展的过程，从单纯ALS、伴有中间认知缺陷的ALS到ALS-FTD。伴有中间认知障碍的ALS患者在PET检查下显示独特的代谢模式。

18F-FDG-PET允许医生无创评估神经退行性疾病患者皮质损伤负荷，可能有助于研究ALS疾病进展过程与神经心理测试的关联，显示可能存在的认知能力损害的早期代谢特征。

原始出处：

Antonio Canosa, Marco Pagani, Angelina Cistaro, et all. 18F-FDG-PET correlates of cognitive impairment in ALS. Neurology. Published online before print November 20,2015.

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2017-02-13 李东泽

很好，不错，以后会多学习

75 0
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2016-10-07 李东泽

好，很好，不错，以后会多学习

77 0
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2016-07-25 feather89

#PE#

40 0
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2016-06-28 yinhl1978

#Neurol#

0 0
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2015-11-26 ms7514935887898259

#PET#

41 0

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