Circulation：心血管风险预测功能在HIV感染患者中是否适用？

2018-02-19 MedSci MedSci原创

艾滋病毒感染者的心血管疾病（CVD）风险升高，既有传统风险因素，也有非传统风险因素。目前已经建立的艾滋病毒相关CVD风险预测功能的准确性尚不确定。近期，一项发表在杂志Circulation上的研究旨在评估三个已建立的心血管疾病风险预测功能在艾滋病毒感染男性患者的纵向队列中的表现。研究者们将Framingham心脏研究（Framingham）的冠心病（Framingham CHD），动脉粥样硬化CV

艾滋病毒感染者的心血管疾病（CVD）风险升高，既有传统风险因素，也有非传统风险因素。目前已经建立的艾滋病毒相关CVD风险预测功能的准确性尚不确定。

近期，一项发表在杂志Circulation上的研究旨在评估三个已建立的心血管疾病风险预测功能在艾滋病毒感染男性患者的纵向队列中的表现。

研究者们将Framingham心脏研究（Framingham）的冠心病（Framingham CHD），动脉粥样硬化CVD（Framingham ASCVD）和美国心脏病学会/美国心脏协会（ACC / AHA ASCVD）功能应用于艾滋病毒伙伴队列。在1/1/2006和12/31/2008之间计算风险评分。结果包括Framingham CHD功能的CHD（心肌梗塞[MI]或冠状动脉死亡）和Framingham ASCVD和ACC/AHA ASCVD功能的ASCVD（MI，卒中或冠状动脉死亡）。使用Cox回归系数，辨别和校准的对比，调查了应用HIV队列时各项CVD风险预测的准确性。

此项研究结果显示：艾滋病毒队列由1280名男性组成，随访时间平均为4.4年。有80例（6.3％）ASCVD事件; 5年发病率为16.7/1000人年。低c统计显示分辨力中等至差（Framingham CHD为0.68，ACC/AHA为0.65，Framingham ASCVD为0.67）。

此项研究结果表明：用于普通人群的心血管风险预测功能在HIV感染者中并不准确，并且系统地低估了HIV感染男性群体的风险。

原始出处：
Triant VA1, Perez J, et al. Cardiovascular Risk Prediction Functions Underestimate Risk in HIV Infection. Circulation. 2018 Feb 14. pii: CIRCULATIONAHA.117.028975. doi: 10.1161/CIRCULATIONAHA.117.028975.

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2018-12-29 ms5353107019656438

#血管风险#

79 0
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2018-04-01 Drhzm308

哦哦哦.知道了

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2018-02-21 jyzxjiangqin

心血管风险预测功能的适用.

115 0
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2018-02-21 智智灵药

#风险预测#

63 0
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2018-02-20 清风拂面

谢谢分享学习

144 0
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2018-02-19 orangesking

好

122 0
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createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Mon Feb 19 19:52:43 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289208, encodeId=0194289208f3, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Mon Feb 19 17:23:26 CST 2018, time=2018-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=289201, encodeId=d29f289201e7, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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2018-02-19 有备才能无患

艾滋病毒感染者的心血管疾病(CVD)风险升高.既有传统风险因素.也有非传统风险因素.目前已经建立的艾滋病毒相关CVD风险预测功能的准确性尚不确定.

1 0
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2018-02-19 1e0f8808m18(暂无匿称)

学习了.谢谢分享.

71 0
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2018-02-19 131****1460

学习了受益匪浅

74 0
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2018-02-19 sunfeifeiyang

阅

57 0