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Eur Heart J:HIV感染者的胸腹主动脉瘤发生率升高了4倍!

2021-07-13 MedSci原创 MedSci原创

与未感染的对照组相比,HIV感染者患主动脉瘤的几率高出四倍,而且HIV状态与主动脉瘤独立相关

联合抗逆转录病毒疗法的引入极大地改善了HIV感染者(PLWH)的预后,但HIV感染者的长期存活率仍然低于未感染者,部分原因是HIV感染者的血管疾病 (CVD) 的发病率增加。据报道,与普通人群相比,HIV感染者发生动脉粥样硬化性CVD的可能性是其两倍。

但是,HIV感染者主动脉瘤的患病率仍未明确。Julie等人调查了HIV状态是否与主动脉瘤独立相关,还评估了与HIV感染者主动脉瘤相关的风险因素。

在HIV感染研究中招募了594位40岁及以上的HIV感染者,并从普通人群研究中招募了1188位年龄和性别相匹配的非感染对照。根据欧洲心脏病学会指南定义主动脉瘤:即主动脉扩张≥50%或肾下主动脉直径≥30 mm。

两组受试者的主动脉瘤风险比

HIV感染者和非感染对照的中位年龄分别是52岁(47-60)和52(48-61),男性分别占88%和90%。在42位(7.1%)HIV感染者中发现了46例主动脉瘤,在29位(2.4%)非感染者中发现了31例主动脉瘤(p<0.001)HIV感染者的升主动脉瘤和肾下主动脉瘤的患病率明显较非感染者高。在校正模型中,HIV感染与主动脉瘤独立相关(校正优势比 4.51, 95%CI 2.56-8.08;p<0.001)。在HIV感染者中,肥胖和乙肝病毒共感染也与主动脉瘤相关。

总结示意图

综上所述,与未感染的对照组相比,HIV感染者患主动脉瘤的几率高出四倍,而且HIV状态与主动脉瘤独立相关。在HIV感染者中,年龄、肥胖和合并乙型肝炎感染均与主动脉瘤的发生率较高相关。该研究结果表明,增加对HIV感染者主动脉瘤的关注可能是有益的。

原始出处:

Hogh Julie,Pham Michael Huy Cuong,Knudsen Andreas Dehlbok et al. HIV infection is associated with thoracic and abdominal aortic aneurysms: a prospective matched cohort study.[J] .Eur Heart J, 2021, https://doi.org/10.1093/eurheartj/ehab348

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    2021-07-17 1defa3ccm19(暂无匿称)

    学习

    0

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1826709, encodeId=dd051826e091e, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Sun May 01 02:03:28 CST 2022, time=2022-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1000323, encodeId=4627100032331, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ed251735729, createdName=1defa3ccm19(暂无匿称), createdTime=Sat Jul 17 10:04:35 CST 2021, time=2021-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290240, encodeId=b9331290240ef, content=<a href='/topic/show?id=f774890827' target=_blank style='color:#2F92EE;'>#HIV感染者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8908, encryptionId=f774890827, topicName=HIV感染者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f65b226, createdName=circumcision, createdTime=Thu Jul 15 00:03:28 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357739, encodeId=99f9135e73991, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Thu Jul 15 00:03:28 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415763, encodeId=dad01415e63bd, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Jul 15 00:03:28 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429083, encodeId=81731429083f8, content=<a href='/topic/show?id=ee192321560' target=_blank style='color:#2F92EE;'>#主动脉瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23215, encryptionId=ee192321560, topicName=主动脉瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95e34160730, createdName=fengting4, createdTime=Thu Jul 15 00:03:28 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1563488, encodeId=97df15634886f, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Thu Jul 15 00:03:28 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999140, encodeId=89e69991404b, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d612028636, createdName=81252974, createdTime=Tue Jul 13 17:08:05 CST 2021, time=2021-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999073, encodeId=6a0a9990e3c7, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210713/5b6c4c53d31b421f941a2895af3f191c/b6a9f7fa62ab471ca96ffde179aca1d8.jpg, createdBy=04ea5472893, createdName=精灵宝贝1, createdTime=Tue Jul 13 12:06:45 CST 2021, time=2021-07-13, status=1, ipAttribution=)]
    2021-07-15 zhaojie88
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    2021-07-15 slcumt
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    2021-07-13 81252974

    学习了

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    2021-07-13 精灵宝贝1

    0

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