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Chest:OSA和心血管疾病合并症患者长期使用CPAP对体重的影响

2018-09-28 xing.T MedSci原创

由此可见,同时患有OSA和心血管疾病的患者长期使用CPAP不会导致临床显著的体重变化。

最近的证据表明阻塞性睡眠呼吸暂停(OSA)治疗可能导致体重增加,但持续气道正压通气(CPAP)对体重的长期影响尚未确定。

近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员对睡眠呼吸暂停血管终点(SAVE)研究进行事后分析,这是一项多中心、随机试验,比较了接受CPAP和标准治疗与单纯标准治疗的有心脏或脑血管事件的中重度OSA患者。评估指标包括在基线和随访期间测量的体重、体重指数(BMI)以及颈围和腰围。线性混合模型用于评估性别特异性时间差异,并且灵敏度分析对较高CPAP依从者(≥4小时/晚)与倾向匹配对照参与者进行了比较。

该研究纳入了2483名成人(接受CPAP治疗1248名和对照组1235名)(体重测量平均差异为6.1±1.5的)。平均随访3.78年后,CPAP组与对照组之间的体重变化没有差异,男性(平均[95%置信区间]组间差异为0.07 [-0.40至0.54] kg; p =0.773);女性为-0.14 [-0.37至0.09] kg; p=0.233)。同样,BMI或其他人体测量指标也没有显著差异。虽然使用CPAP≥4小时/夜的男性参与者体重略高于没有进行CPAP的对照组(平均差异为0.38 [0.04至0.73] kg; p=0.031),但其它人体测量变量之间没有组间差异,女性高CPAP依从者与匹配对照者之间也没有差异。

由此可见,同时患有OSA和心血管疾病的患者长期使用CPAP不会导致临床显著的体重变化。

原始出处:


Qiong Ou,et al. The effects of long-term CPAP on weight change in patients with co-morbid OSA and cardiovascular disease: data from the SAVE trial.chest.2018. https://journal.chestnet.org/article/S0012-3692(18)32482-6/fulltext

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    2018-12-16 Smile2680
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    2018-09-30 bioon3
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    2018-09-28 医者仁心5538

    学习了

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