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Diabetes Care:糖尿病患者和非糖尿病患者心肌缺血负担和预后差异

2019-11-29 xing.T MedSci原创

由此可见,对于TPD>0%的各个水平,甚至0%<TPD<1%的极小缺失,糖尿病患者发生MACE风险都比非糖尿病患者高。缺血程度最低的糖尿病患者MACE风险与缺血程度明显的非糖尿病患者相当。

糖尿病患者和非糖尿病患者心血管疾病的患病率和预后是不同的。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在通过自动定量糖尿病患者和非糖尿病患者的总灌注缺失(TPD)来探讨心肌缺血的患病率和预后的差异。

在20418例接受单光子发射计算机断层扫描心肌灌注成像的患者中,使用倾向评分,根据危险因素将2951名糖尿病患者与2951名非糖尿病患者进行匹配。TPD分为TPD=0%、0%-1%、1%-5%、5%-10%和>10%。主要不良心血管事件(MACE)被定义为全因死亡率、心肌梗塞、不稳定型心绞痛或晚期血运重建的复合事件。

在TPD均高于0的情况下,与非糖尿病患者相比,糖尿病患者的MACE风险增加了(相互作用P<0.001)。在TPD>10%的患者,与非糖尿病患者相比,糖尿病患者MACE风险高出两倍(年化MACE率分别为9.4 [95%CI为6.7-11.6]和3.9 [95%CI为2.8-5.6],P<0.001)。TPD极低(0%-1%)的糖尿病患者发生MACE的风险高于TPD为0%的糖尿病患者(风险比为2.05,95%CI为1.21-3.47,P=0.007)。TPD为0.5%的糖尿病患者MACE风险与TPD为8%的非糖尿病患者相似。

由此可见,对于TPD>0%的各个水平,甚至0%

原始出处:


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    2019-12-01 天地飞扬

    学习

    0

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    2019-11-29 misszhang

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