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Nature Catalysis:利用磁力将药物直接输送到癌症组织,有望治愈癌症患者

2018-02-03 榕榕 来宝网

佐治亚大学的一个研究小组开发了一种非侵入性方法,利用磁力将药物直接输送到癌症组织,这种治疗方法可以显着减少化疗的毒副作用。

【基于磁性的药物递送系统显示出对癌症治疗的希望】佐治亚大学的一个研究小组开发了一种非侵入性方法,利用磁力将药物直接输送到癌症组织,这种治疗方法可以显着减少化疗的毒副作用。

UGA大学家庭与消费科学学院纳米结构材料实验室的研究生Andrey Zakharchenko说:“我们证明,我们可以在需要的地方提供抗癌药物,并且可以杀死癌细胞。

纽约UGA和克拉克森大学的研究人员首先创建了非常好的纳米颗粒,作为药物载体,其中一个载有药物的底物基质,另一个载有酶。

在施加相对较弱的磁场时,两个纳米颗粒合并,迫使在特定位置释放药物的反应。

通过控制相互作用的时机,研究人员可以确定药物的输送位置,从而预防化疗的副作用,如脱发或心脏毒性。

研究人员使用化疗药物和癌细胞进行了体外概念研究的证明。 Zakharchenko说,下一步将是开发一个动物模型。

美国乔治亚州纤维和聚合物科学教授Sergiy Minko表示:“使用静态磁场引起反应非常重要,因为它不会对身体构成威胁。” Sergiy MinkoFACS为纺织品,商品和室内装饰部门的乔治亚州电力学教授,属于艺术与科学学院化学系。

在以前的研究中,脉动磁场已经被用来传递药物,但是应用所产生的热量会破坏患者的健康细胞。

这篇文章出现在一月份的“自然催化”杂志上。

原始出处:

Andrey Zakharchenko, Nataliia Guz, Amine Mohamed Laradji,et al. Magnetic field remotely controlled selective biocatalysis. Nature Catalysisvolume 1, pages73–81 (2018), doi:10.1038/s41929-017-0003-3.

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    2018-02-06 一叶知秋
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    2018-02-05 bbjsj_1981

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