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ENVIRON HEALTH：女性工作环境与乳腺癌密切相关

2013-01-04 ENVIRON HEALTH 好医365

工作环境职业暴露乳腺癌
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　　北爱尔兰科学家经过研究发现，女性的工作环境会对其患乳腺癌的风险产生重大的影响。 　　研究人员称，一些从事工业生产活动的女性由于长期接触有毒化学物质，她们患乳腺癌的风险是其他女性的5倍。 　　来自贝尔法斯特女王大学(Queen’s University in Belfast)和斯特林大学(University of Stirling)的研究人员发现，从事农业生产、塑料生产、食品装罐、金属制造


　　北爱尔兰科学家经过研究发现，女性的工作环境会对其患乳腺癌的风险产生重大的影响。

　　研究人员称，一些从事工业生产活动的女性由于长期接触有毒化学物质，她们患乳腺癌的风险是其他女性的5倍。

　　来自贝尔法斯特女王大学(Queen’s University in Belfast)和斯特林大学(University of Stirling)的研究人员发现，从事农业生产、塑料生产、食品装罐、金属制造的女性以及在酒吧、娱乐场所工作的女性更容易患上乳腺癌。

　　研究对2000多名女性进行了调查，研究还发现在高化学物环境中工作长达10年的女性患乳腺癌的风险会上升42%。

　　该研究的调查对象包括1006名乳腺癌女性和1147名没有患乳腺癌的女性，相关的研究成果被发表在公共健康杂志《环境健康》上。

　　研究发现，从事农业生产活动的女性患乳腺癌的风险会上升36%。这些女性长期接触的一些农药会扮演乳腺致癌物的角色，她们的内分泌系统(向体内分泌激素的腺体网)也会积累一些破坏性化学物。

　　同时，在酒吧和娱乐产所工作的女性患乳腺癌的风险会增加1倍，可能是长期接触二手烟所致。

　　此外，从事汽车工业和塑料生产的女性患乳腺的风险同样会翻倍，而如果从事这些工作的女性尚未进入更年期，其患癌风险将是其他人的5倍。很多塑料都会释放能致癌的化学物质，而长期接触这些化学物将对人体健康造成很大影响。

　　该研究是由斯特林大学职业与环境健康研究小组(OEHRG)以及女王大学管理学院的研究人员共同组织进行的。

　　研究小组组长Andrew Watterson教授表示：“包括研究对象在内的很多女性在工作中都会接触到有毒化学物质，而就乳腺癌病因所涉及的工作类型和领域进行探索将是一个全球性的课题。”

　　女性从事的行业以及对应的乳腺癌风险上升幅度：

　　· 塑料生产：风险加倍;

　　· 食品装罐：风险加倍;

　　· 酒吧、娱乐场所：风险加倍;

　　· 金属制造、加工：风险增加73%;

　　· 农业生产：风险增加36%。

与乳腺癌相关的拓展阅读：


Breast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: a Canadian case–control study

Background
Endocrine disrupting chemicals and carcinogens, some of which may not yet have been classified as such, are present in many occupational environments and could increase breast cancer risk. Prior research has identified associations with breast cancer and work in agricultural and industrial settings. The purpose of this study was to further characterize possible links between breast cancer risk and occupation, particularly in farming and manufacturing, as well as to examine the impacts of early agricultural exposures, and exposure effects that are specific to the endocrine receptor status of tumours.
Methods
1005 breast cancer cases referred by a regional cancer center and 1146 randomly-selected community controls provided detailed data including occupational and reproductive histories. All reported jobs were industry- and occupation-coded for the construction of cumulative exposure metrics representing likely exposure to carcinogens and endocrine disruptors. In a frequency-matched case–control design, exposure effects were estimated using conditional logistic regression.
Results
Across all sectors, women in jobs with potentially high exposures to carcinogens and endocrine disruptors had elevated breast cancer risk (OR = 1.42; 95% CI, 1.18-1.73, for 10 years exposure duration). Specific sectors with elevated risk included: agriculture (OR = 1.36; 95% CI, 1.01-1.82); bars-gambling (OR = 2.28; 95% CI, 0.94-5.53); automotive plastics manufacturing (OR = 2.68; 95% CI, 1.47-4.88), food canning (OR = 2.35; 95% CI, 1.00-5.53), and metalworking (OR = 1.73; 95% CI, 1.02-2.92). Estrogen receptor status of tumors with elevated risk differed by occupational grouping. Premenopausal breast cancer risk was highest for automotive plastics (OR = 4.76; 95% CI, 1.58-14.4) and food canning (OR = 5.70; 95% CI, 1.03-31.5).
Conclusions
These observations support hypotheses linking breast cancer risk and exposures likely to include carcinogens and endocrine disruptors, and demonstrate the value of detailed work histories in environmental and occupational epidemiology.

    

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    2013-02-07 shizhenshan

    #ALT#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1860947, encodeId=296b186094ee9, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Thu Feb 07 21:49:00 CST 2013, time=2013-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2085364, encodeId=1dd320853644d, content=<a href='/topic/show?id=9c2d4e90154' target=_blank style='color:#2F92EE;'>#工作环境#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47901, encryptionId=9c2d4e90154, topicName=工作环境)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e4137, createdName=meichuangyi, createdTime=Tue May 28 01:49:00 CST 2013, time=2013-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524179, encodeId=b18315241e931, content=<a href='/topic/show?id=053710045ad' target=_blank style='color:#2F92EE;'>#iron#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10045, encryptionId=053710045ad, topicName=iron)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1b11597510, createdName=july_979, createdTime=Sun Jan 06 07:49:00 CST 2013, time=2013-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621487, encodeId=636d162148e00, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Sun Jan 06 07:49:00 CST 2013, time=2013-01-06, status=1, ipAttribution=)]
    2013-05-28 meichuangyi

    #工作环境#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1860947, encodeId=296b186094ee9, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Thu Feb 07 21:49:00 CST 2013, time=2013-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2085364, encodeId=1dd320853644d, content=<a href='/topic/show?id=9c2d4e90154' target=_blank style='color:#2F92EE;'>#工作环境#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47901, encryptionId=9c2d4e90154, topicName=工作环境)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e4137, createdName=meichuangyi, createdTime=Tue May 28 01:49:00 CST 2013, time=2013-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524179, encodeId=b18315241e931, content=<a href='/topic/show?id=053710045ad' target=_blank style='color:#2F92EE;'>#iron#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10045, encryptionId=053710045ad, topicName=iron)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1b11597510, createdName=july_979, createdTime=Sun Jan 06 07:49:00 CST 2013, time=2013-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621487, encodeId=636d162148e00, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Sun Jan 06 07:49:00 CST 2013, time=2013-01-06, status=1, ipAttribution=)]
    2013-01-06 july_979

    #iron#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1860947, encodeId=296b186094ee9, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Thu Feb 07 21:49:00 CST 2013, time=2013-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2085364, encodeId=1dd320853644d, content=<a href='/topic/show?id=9c2d4e90154' target=_blank style='color:#2F92EE;'>#工作环境#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47901, encryptionId=9c2d4e90154, topicName=工作环境)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e4137, createdName=meichuangyi, createdTime=Tue May 28 01:49:00 CST 2013, time=2013-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1524179, encodeId=b18315241e931, content=<a href='/topic/show?id=053710045ad' target=_blank style='color:#2F92EE;'>#iron#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10045, encryptionId=053710045ad, topicName=iron)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f1b11597510, createdName=july_979, createdTime=Sun Jan 06 07:49:00 CST 2013, time=2013-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621487, encodeId=636d162148e00, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Sun Jan 06 07:49:00 CST 2013, time=2013-01-06, status=1, ipAttribution=)]
    2013-01-06 yyanpro@28cn.c

    #Health#

    0

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